Table 5 Characteristic of recently hospitalized initiators and non-initiators with PD
From: Recent hospitalization and risk of antidepressant initiation in people with Parkinson’s disease
Characteristic | Hospitalized Initiators (n = 2653) | Hospitalized non-initiators (n = 788) | P value |
|---|---|---|---|
Age at index datea, mean (95% CI) | 73.2 (72.8–73.5) | 73.5 (72.8–74.1) | 0.48 |
Time since PD diagnosis, median (IQR) | 3.0 (1.2–5.6) | 2.8 (1.2–5.6) | 0.11 |
Sex, n (%) | 0.04 | ||
Women | 1363 (51.4) | 438 (55.6) | |
Men | 1290 (48.6) | 350 (44.4) | |
Comorbidities, n (%) | |||
Cardiovascular diseases | 1118 (42.1) | 185 (23.5) | < 0.001 |
Asthma/COPD | 234 (8.8) | 50 (6.4) | 0.03 |
Diabetes | 309 (11.7) | 38 (4.8) | < 0.001 |
PD medication use, n (%) | |||
Any medication for PD | 2511 (94.7) | 718 (91.1) | < 0.001 |
Dopaminergic medication for PD | 2502 (94.3) | 717 (91.0) | 0.001 |
Dopa and dopa derivatives | 2191 (82.6) | 595 (75.5) | < 0.001 |
Dopamine agonists | 1205 (45.4) | 353 (44.8) | 0.76 |
Monoamine oxidase B inhibitors | 930 (35.1) | 301 (38.2) | 0.11 |
Other dopaminergic agents | 142 (5.4) | 45 (5.7) | 0.70 |
Other medication use, n (%) | |||
Opioids | 486 (18.3) | 116 (14.7) | 0.020 |
Antipsychotics | 286 (10.8) | 77 (9.8) | 0.42 |
Benzodiazepines and related drugs | 839 (31.6) | 132 (16.8) | < 0.001 |
Acetylcholinesterase inhibitors (AChEI) | 151 (5.7) | 45 (5.7) | 0.98 |
Memantine | 23 (0.9) | 11 (1.4) | 0.19 |
AChEI/memantine | 158 (6.0) | 48 (6.1) | 0.89 |