Table 1 Characteristics of antidepressant initiators and matched non-initiators with PD
From: Recent hospitalization and risk of antidepressant initiation in people with Parkinson’s disease
Characteristic | Initiators (n = 5492) | Non-initiators (n = 5492) | P Value |
|---|---|---|---|
Age at index datea, mean (95% CI) | 73.5 (73.3–73.8) | 73.6 (73.4–73.9) | Matched |
Time since PD diagnosisa, median (IQR) | 2.9 (1.1–5.5) | 2.8 (1.1–5.5) | Matched |
Sex, n (%) | Matched | ||
Women | 2873 (52.3) | 2873 (52.3) | |
Men | 2619 (47.7) | 2619 (47.7) | |
Hospitalization within 14 days before the index datea, n (%) | 2653 (48.3) | 788 (14.3) | < 0.001 |
Comorbidities, n (%) | |||
Cardiovascular diseases | 2356 (42.9) | 1285 (23.4) | < 0.001 |
Asthma/COPD | 442 (8.1) | 243 (4.4) | < 0.001 |
Diabetes | 610 (11.1) | 309 (5.6) | < 0.001 |
PD medication use, n (%) | |||
Any medication for PD | 5202 (94.7) | 4815 (87.7) | < 0.001 |
Dopaminergic medication for PD | 5178 (94.3) | 4793 (87.3) | < 0.001 |
Dopa and dopa derivatives | 4536 (82.6) | 3882 (70.7) | < 0.001 |
Dopamine agonists | 2304 (42.0) | 2246 (40.9) | 0.26 |
Monoamine oxidase B inhibitors | 1961 (35.7) | 2003 (36.5) | 0.41 |
Other dopaminergic agents | 290 (5.3) | 222 (4.0) | 0.002 |
Other medication use, n (%) | |||
Opioids | 860 (15.7) | 504 (9.2) | < 0.001 |
Antipsychotics | 571 (10.4) | 355 (6.5) | < 0.001 |
Benzodiazepines and related drugs | 1831 (33.3) | 835 (15.2) | < 0.001 |
Acetylcholinesterase inhibitors (AChEI) | 389 (7.1) | 289 (5.3) | < 0.001 |
Memantine | 62 (1.1) | 52 (1.0) | 0.35 |
AChEI/memantine | 406 (7.4) | 307 (5.6) | < 0.001 |