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Table 4 Sensitivity analysis of the association between eGDRBMI and risk of CVD, stroke and cardiac events

From: Estimated glucose disposal rate and risk of cardiovascular disease: evidence from the China Health and Retirement Longitudinal Study

Characteristics

eGDR(mg/kg/min)

P trend

Each SD increasea

 < 8.99

8.99–10.52

10.52–11.22

 ≥ 11.22

Sensitivity analysis 1

CVD

  Multivariable-adjustedb

1.00(Ref)

0.95(0.83–1.08)

0.73(0.63–0.84)

0.59(0.51–0.69)

 < 0.001

0.84(0.80–0.88)

Stroke

  Multivariable-adjustedb

1.00(Ref)

0.99(0.79–1.25)

0.85(0.63–1.15)

0.84(0.65–0.98)

0.009

0.91(0.85–0.99)

Cardiac events

  Multivariable-adjustedb

1.00(Ref)

0.96(0.83–1.12)

0.71(0.61–0.84)

0.55(0.46–0.66)

 < 0.001

0.84(0.79–0.88)

Sensitivity analysis 2

CVD

  Multivariable-adjustedb

1.00(Ref)

0.91(0.79–1.05)

0.66(0.57–0.77)

0.56(0.47–0.65)

 < 0.001

0.82(0.77–0.86)

Stroke

  Multivariable-adjustedb

1.00(Ref)

0.92(0.72–1.18)

0.73(0.56–0.97)

0.64(0.47–0.88)

0.003

0.88(0.79–0.98)

Cardiac events

  Multivariable-adjustedb

1.00(Ref)

0.92(0.78–1.09)

0.66(0.55–0.79)

0.55(0.46–0.67)

 < 0.001

0.82(0.77–0.87)

  1. In sensitivity analysis 1, the eGDRBMI was calculated based on BMI. In sensitivity analysis 2, those with anti-diabetes/hypertension drugs use were excluded
  2. CVD Cardiovascular diseases, eGDR Estimated glucose disposal rate
  3. aEach SD increase in eGDR (1.71 mg/kg/min)
  4. bMultivariable-adjusted for age, sex, place of residence, education level, blood glucose, smoking, drinking, systolic blood pressure, physical activity, chronic diseases (dyslipidemia, chronic lung disease) and medications (anti-hypertensive and anti-dyslipidemic)