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Table 2 Modifiable Risk Factors, Apolipoprotein E4 Genotype, and their Joint Effects as Predictors of Incident Cognitive Impairment No Dementia (CIND)

From: Interactions between the apolipoprotein E4 gene and modifiable risk factors for cognitive impairment: a nationally representative panel study

Risk Factor

 

Hazard Ratio

95% CI Lower Bound

95% CI Upper Bound

p -value

 ≤ High School Education

Joint Effect

3.61

1.51

8.61

0.0039

Risk Factor Effect

1.61

0.68

3.80

0.2811

APOE4 Effect

1.65

0.52

5.23

0.3986

Hypertension

Joint Effect

2.46

1.28

4.73

0.0068

Risk Factor Effect

1.36

0.76

2.41

0.2981

APOE4 Effect

2.65

1.35

5.20

0.0046

Type 2 Diabetes

Joint Effect

1.58

0.71

3.50

0.2611

Risk Factor Effect

1.29

0.67

2.48

0.4400

APOE4 Effect

2.51

1.54

4.09

0.0002

Depressive Symptoms

Joint Effect

5.09

2.59

10.02

 < .0001

Risk Factor Effect

1.26

0.68

2.32

0.4622

APOE4 Effect

1.81

1.09

3.03

0.0229

Hearing Loss

Joint Effect

3.44

1.87

6.33

 < .0001

Risk Factor Effect

0.58

0.27

1.25

0.1659

APOE4 Effect

1.83

1.13

2.96

0.0141

Vision Impairment

Joint Effect

5.14

2.31

11.43

 < .0001

Risk Factor Effect

1.18

0.59

2.37

0.6369

APOE4 Effect

1.84

1.12

3.04

0.0168

Smoking

Joint Effect

2.35

1.24

4.47

0.0090

Risk Factor Effect

1.26

0.66

2.39

0.4797

APOE4 Effect

2.66

1.24

5.72

0.0120

Obesity

Joint Effect

3.80

2.11

6.85

 < .0001

Risk Factor Effect

1.22

0.60

2.47

0.5840

APOE4 Effect

1.90

1.15

3.14

0.0117