Certainty assessment | Certainty | Importance |
|---|
№ of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations |
|---|
2 | observational studies | seriousa | seriousb | not serious | seriousc | none | ⨁◯◯◯ Very low | CRITICAL |
- aSee Risk of Bias section in results and Additional file 1: APPENDIX F
- bThe results of the two studies were not consistent
- cThe study by Leung et al. [52] had a large sample size (n = 5395) and unbalanced exposure groups (exposed = 295, 5.5% vs. unexposed = 4949, 92.5%). The study by In-sook et al. had a medium sample size (n = 601); this study did not report the number of persons with AD and persons without AD [51]
