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Table 2 Adjusted changes and 95% CIs in predicted functional limitation, gait speed, and grip strength with multimorbidity for each 1 point-increase in the Multimorbidity-Weighted Index

From: Multimorbidity and long-term disability and physical functioning decline in middle-aged and older Americans: an observational study

 

Disability (N = 16,616)

Gait speed (N = 2,748)

Grip strength (N = 2,748)

 

Model 1

IRR

(95% CI)

Model 2

IRR

(95% CI)

Model 1

β

(95% CI)

Model 2

β

(95% CI)

Model 1

β

(95% CI)

Model 2

β

(95% CI)

MWI

1.07

(1.07, 1.08)

p < 0.0001

1.10

(1.09, 1.10)

p < 0.0001

-0.004

(-0.005, -0.003)

p < 0.0001

-0.004

(-0.006, -0.001)

p < 0.0001

-0.06

(-0.09, -0.04)

p < 0.0001

-0.01

(-0.73, 0.04)

p < 0.0001

Time

1.10

(1.09, 1.10)

p < 0.0001

1.13

(1.12, 1.14)

p < 0.0001

-0.01

(-0.02, -0.01)

p < 0. 0001

-0.01

(-0.02, -0.01)

p = 0.004

-0.66

(-0.72, -0.60)

p < 0.0001

-0.59

( -0.68, -0.49)

p = 0.63

MWI*Time

-

0.998

(0.997, 0.998)

p < 0.0001

-

0.00002

(-0.0004, 0.0004)

p = 0.92

-

-0.008

(-0.02, 0.0005)

p = 0.06

  1. Abbreviations: β Regression coefficient, IRR Incidence rate ratio, MWI Multimorbidity-Weighted Index
  2. Legend:
  3. Significant results are bolded
  4. Covariates: sex, ethnicity (Non-Hispanic White, Non-Hispanic Black, Hispanic, Other), years of education (less than high school, high school, college, ≥ 4 years of college), BMI category (< 18.5, 18.5–24.9, 25–29.9, ≥ 30 kg/m2), smoking status (never smoked, past smoker, current smoker), living arrangement (married, unmarried and lives with another, unmarried and lives alone), household net worth by quartiles, time (years since baseline)
  5. Model 1 (modeling change in intercept): independent variables included the predictor time-varying MWI, all covariates, and outcome measure at baseline for each respective outcome (i.e., disability at baseline for disability model, gait speed at baseline for gait speed model or grip strength at baseline for grip strength model)
  6. Model 2 (modeling change in slope): Model 1 with additional interaction between MWI and time