Table 6 Known-groups validity: Differences in ADCS-ADL-MCI scores between severity groups at baseline and month 36

APOE ε4 allele carrierStatus

 Carrier

423

46.04 (4.41)

0.5443

262

38.02 (11.44)

 < 0.001

 Non-Carrier

345

45.83 (5.19)

215

43.80 (9.45)

GDS Categories

 No/very mild cognitive decline

293

46.76 (4.89)

 < 0.001

141

48.16 (3.54)

 < 0.001

 Mild cognitive decline

435

45.67 (4.59)

163

44.56 (6.12)

 Moderate cognitive decline

40

43.00 (4.52)

170

30.65 (11.29)

MMSE Categories

  ≥ 27

505

46.45 (4.57)

 < 0.001

250

46.24 (5.65)

 < 0.001

  < 27

263

44.99 (5.01)

227

34.45 (12.04)

MMSE Quintiles

 Quintile 1 (> 29)

93

47.59 (3.62)

 < 0.001

73

48.4 (3.64)

 < 0.001

 Quintile 2 (> 28 and ≤ 29)

143

47.01 (4.20)

73

46.56 (4.65)

 Quintile 3 (> 27 and ≤ 28)

135

46.21 (4.11)

54

44.72 (7.38)

 Quintile 4 (> 25 and ≤ 27)

240

45.36 (5.13)

91

43.64 (6.68)

 Quintile 5 (≤ 25)

157

44.69 (5.34)

186

32.59 (12.1)

BDI Categories

 Normal (0–10)

587

46.34 (4.41)

 < 0.001

309

43.5 (9.07)

 < 0.001

 Abnormal (> 10)

171

44.64 (5.56)

158

34.82 (12.25)

BDI Quintiles

 Quintile 1 (≤ 2)

159

47.66 (3.94)

 < 0.001

84

47.88 (5.36)

 < 0.001

 Quintile 2 (> 2 and ≤ 5)

205

46.42 (4.14)

91

44.21 (7.62)

 Quintile 3 (> 5 and ≤ 7)

99

45.55 (4.34)

59

43.14 (8.73)

 Quintile 4 (> 7 & ≤ 11)

165

45.42 (4.94)

95

38.51 (11.12)

 Quintile 5 (> 11)

130

44.14 (5.73)

138

34.02 (12.3)

CDR-SB Categories

  < 2.5

545

46.93 (4.11)

 < 0.001

234

47.57 (4.17)

 < 0.001

  ≥ 2.5

223

43.55 (5.40)

236

33.85 (11.20)

CDR-SB Quintiles

 Quintile 1 (≤ 1)

197

47.77 (3.82)

 < 0.001

148

48.09 (3.78)

 < 0.001

 Quintile 2 (= 1.5)

191

46.50 (4.07)

47

47.74 (3.71)

 Quintile 3 (= 2)

157

46.41 (4.36)

39

45.38 (5.36)

 Quintile 4 (= 2.5)

139

44.25 (5.02)

34

43.21 (6.47)

 Quintile 5 (> 2.5)

84

42.39 (5.82)

202

32.28 (11.07)