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Table 2 Scores on reference measures included in the ADC-008 trial at baseline and month 36

From: Psychometric properties of the Alzheimer’s Disease Cooperative Study – Activities of Daily Living for Mild Cognitive Impairment (ADCS-MCI-ADL) scale: a post hoc analysis of the ADCS ADC-008 trial

Instrument

Baseline (n = 769)

Month 36 (n = 484)

ADCS-ADL-MCI a¥

 Mean (SD)

45.95 (4.77)

40.63 (10.97)

 Median (IQR)

47 (44—49.5)

45 (35—49)

 Min, Max

18, 53

3, 53

 Missing (n)

1

7

Global Deterioration Scale, n (%)¥

 No cognitive decline

4 (0.52)

9 (1.86%)

 Very mild cognitive decline

289 (37.58)

134 (27.69%)

 Mild cognitive decline

436 (56.70)

165 (34.09%)

 Moderate cognitive decline

40 (5.20)

91 (18.80%)

 Moderately severe cognitive decline

0 (0)

68 (14.05%)

 Severe cognitive decline

0 (0)

11 (2.27%)

 Missing (n)

0

6

MMSE, mean (SD) ¥

27.27 (1.85)

25.28 (4.79)

 Missing (n)

0

4

CDR-SB, mean (SD) ¥

1.82 (0.79)

3.17 (2.81)

 Missing (n)

0

11

ADAS-Cog, mean (SD) a

11.28 (4.38)

14.05 (8.73)

 Missing (n)

4

11

BDI, mean (SD)

6.85 (5.18)

8.55 (6.30)

 Missing (n)

11

15

Qol-AD Informant Score, mean (SD) ¥

39.28 (5.49)

37.07 (6.46)

 Missing (n)

22

24

NYU delayed paragraph recall test, mean (SD) ¥

3.54 (2.80)

2.58 (2.66)

 Missing (n)

1

9

Symbol digit modalities test, mean (SD) ¥

31.58 (10.73)

32.19 (13.22)

 Missing (n)

2

17

  1. a Small inconsistencies in scores compared to those reported by Petersen et. al (2005) [19]
  2. ¥ Statistically significant difference in scores between baseline and month 36 (p-value < 0.05) was detected, based on data available at both time points
  3. SD Standard Deviation, IQR Interquartile Range