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Table 3 Associations between cognition-related biomarkers and frailty (n = 375) a

From: Potential association between frailty and pTau in community-dwelling older adults

 

Model 1 b

Model 2 c

Model 3 d

OR (95% CI)

p Value

OR (95% CI)

p Value

OR (95% CI)

p Value

tTau

1.00 (0.76 to 1.31)

0.992

0.98 (0.75 to 1.30)

0.906

0.98 (0.72 to 1.33)

0.891

pTau

1.38 (1.05 to 1.83)

0.023

1.41 (1.06 to 1.87)

0.019

1.40 (1.04 to 1.89)

0.029

NFL

0.88 (0.67 to 1.16)

0.377

0.91 (0.69 to 1.21)

0.518

0.91 (0.67 to 1.23)

0.532

Aβ40

1.01 (0.77 to 1.33)

0.931

1.01 (0.77 to 1.33)

0.956

0.98 (0.73 to 1.31)

0.873

Aβ42

1.05 (0.80 to 1.38)

0.732

1.08 (0.82 to 1.43)

0.583

1.15 (0.85 to 1.56)

0.371

S100B

1.05 (0.80 to 1.37)

0.755

1.04 (0.79 to 1.36)

0.807

1.12 (0.83 to 1.52)

0.465

VLP1

1.27 (0.96 to 1.69)

0.089

1.28 (0.97 to 1.70)

0.086

1.15 (0.84 to 1.56)

0.384

AD7cNTP

1.18 (0.90 to 1.56)

0.233

1.18 (0.89 to 1.55)

0.246

1.29 (0.94 to 1.75)

0.112

βAPP

0.87 (0.66 to 1.14)

0.312

0.88 (0.67 to 1.16)

0.349

0.84 (0.62 to 1.13)

0.25

CHI3L1

1.02 (0.77 to 1.34)

0.905

1.00 (0.76 to 1.32)

0.978

1.08 (0.80 to 1.47)

0.61

sCR1

1.10 (0.83 to 1.44)

0.517

1.9 (0.83 to 1.45)

0.534

1.13 (0.83 to 1.54)

0.439

hFABP

1.07 (0.82 to 1.41)

0.621

1.08 (0.82 to 1.42)

0.601

1.08 (0.80 to 1.45)

0.636

  1. a For per 1-SD increase in cognition-related biomarkers
  2. b Unadjusted
  3. c Adjusted for age and sex
  4. d Adjusted for age, sex, education, marital status, comorbidity, depression, cognition and obesity