Efficacy and safety of adrenergic alpha-1 receptor antagonists in older adults: a systematic review and meta-analysis supporting the development of recommendations to reduce potentially inappropriate prescribing

Table 4 Critical quality appraisal for included interventional studies according to the Cochrane Collaboration Tool [38]

Authors (Year)	Study Type	Selection Bias	Performance Bias	Attrition Bias	Detection Bias	Reporting Bias	Overall risk-of-bias judgement
Authors (Year)	Study Type	Randomization and concealment	Concealment of intervention/outcome	Missing outcome data	Measurement of outcome	Selective reporting	Overall risk-of-bias judgement
ALLHAT (2003) [47]	Randomised double-blind controlled trial	LR	LR	LR	LR	LR	LR
Gotoh et al. (2005) [35]	Randomised controlled trial	SC	LR	HR	SC	SC	HR
Nishino et al. (2006) [36]	Randomised crossover trial	LR	LR	LR	SC	SC	SC
Oelke et al. (2014) [48]	Randomised double-blind placebo-controlled trial	LR	LR	HR	LR	LR	HR
Roehrborn (2006) [49]	Randomised double-blind placebo-controlled trial	LR	LR	HR	LR	LR	HR
Yokoyama et al. (2011) [34]	Randomised controlled trial	LR	LR	HR	SC	SC	HR

ISSN: 1471-2318