Table 6 Univariate logistic regression of grade ≥ 3 toxicity during therapy related to risks in long-term medication (n = 113); distribution of CTCAE grade ≥ 3 toxicity in patients during therapy course per medication risks
Odds ratio (95% CI) | P value | Number of patients with toxicity/number of all patients (%) with vs without medication risk | |
|---|---|---|---|
Overall toxicity | |||
Number of drugs per patient | 1.15 (0.98–1.34) | 0.090 | - |
Patients with vs without (reference) polymedication | 1.52 (0.58–3.95) | 0.391 | 49/58 (84.5) vs 43/55 (78.2) |
Number of PIM per patient | 1.23 (0.71–2.13) | 0.460 | - |
Patients with vs without (reference) at least one PIM | 1.31 (0.51–3.39) | 0.578 | 50/60 (83.3) vs 42/53 (79.2) |
Number of rPDDI per patient | 3.84 (0.97–15.31) | 0.056 | - |
Patients with vs without (reference) at least one rPDDI | 5.07 (1.11–23.14) | 0.036 | 32/34 (94.1) vs 60/79 (75.9) |
Hematological toxicity | |||
Number of drugs per patient | 1.04 (0.93–1.16) | 0.511 | - |
Patients with vs without (reference) polymedication | 1.17 (0.53–2.58) | 0.691 | 40/58 (69.0) vs 36/55 (65.5) |
Number of PIM per patient | 0.91 (0.60–1.36) | 0.642 | - |
Patients with vs without (reference) at least one PIM | 0.94 (0.43–2.08) | 0.887 | 40/60 (66.7) vs 36/53 (67.9) |
Number of rPDDI per patient | 1.59 (0.90–2.80) | 0.111 | - |
Patients with vs without (reference) at least one rPDDI | 3.95 (1.38–11.29) | 0.010 | 29/34 (85.3) vs 47/79 (59.5) |
Nonhematological toxicity | |||
Number of drugs per patient | 1.14 (1.01–1.28) | 0.029 | - |
Patients with vs without (reference) polymedication | 1.47 (0.69–3.12) | 0.318 | 37/58 (63.8) vs 30/55 (54.5) |
Number of PIM per patient | 1.68 (1.05–2.67) | 0.030 | - |
Patients with vs without (reference) at least one PIM | 1.93 (0.90–4.12) | 0.091 | 40/60 (66.7) vs 27/53 (50.9) |
Number of rPDDI per patient | 1.59 (0.95–2.66) | 0.076 | - |
Patients with vs without (reference) at least one rPDDI | 1.66 (0.72–3.87) | 0.238 | 23/34 (67.6) vs 44/79 (55.7) |