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Table 2 Intergroup comparisons of the preoperative serum biochemical parameters

From: Higher serum PGE2 is a predicative biomarker for postoperative delirium following elective orthopedic surgery in elderly patients

Parameters

POD group (n = 35)

Non-POD group (n = 96)

aP value

effect size

BDNF (ng/ml)

0.43(0.38 ~ 0.54)

0.48(0.41 ~ 0.63)

0.109

/

FGF-23 (pg/ml)

504.07(456.31 ~ 577.63)

513.83(466.68 ~ 588.38)

0.894

/

Irisin (ng/ml)

47.64(18.94 ~ 74.45)

63.01(26.67 ~ 115.62)

0.070

/

IL-17A (pg/ml)

6.00(5.71 ~ 6.61)

6.02(5.58 ~ 6.69)

0.320

/

IL-33 (pg/ml)

11.50(5.35 ~ 33.07)

16.21(5.13 ~ 185.00)

0.353

/

C3a (ng/ml)

504.07(456.31 ~ 577.63)

513.83(466.68 ~ 588.38)

0.894

/

C3 (μg/ml)

264.87(136.56 ~ 297.21)

207.81(103.38 ~ 271.51)

0.065

/

C5a (ng/ml)

102.57(52.33 ~ 165.90)

85.77(52.71 ~ 141.67)

0.297

/

iNOS (IU/ml)

8.81(6.21 ~ 13.6)

8.54(6.07 ~ 12.16)

0.274

/

PGE2 (pg/ml)

181.23(126.08 ~ 235.65)

61.63(39.96 ~ 105.65)

 < 0.001

0.61

S100β (pg/ml)

199.22(183.52 ~ 283.19)

181.36(170.91 ~ 207.67)

 < 0.001

0.33

GFAP (ng/ml)

11.76(7.77 ~ 14.61)

7.38(5.84 ~ 10.29)

 < 0.001

0.36

NfL (ng/ml)

1.47 ± 0.2960

1.29 ± 0.2961

0.002

0.60

VCAM1(ng/ml)

691.11 ± 263.50

652.18 ± 196.83

0.364

/

E-selectin (ng/ml)

2.95(2.14 ~ 3.99)

2.79(1.98 ~ 4.26)

0.718

/

MMP9 (ng/ml)

4.00(1.37 ~ 5.32)

3.36(1.71 ~ 9.68)

0.649

/

  1. POD Postoperative delirium, BDNF Brain derived neurotrophic factor, FGF-23 Fibroblast growth factor 23, IL Interleukin, iNOS Inducible nitric oxide synthase, PGE2 Prostaglandin E2, GFAP Glial fibrillary acidic protein, NfL Neurofilament light, VCAM Vascular cell adhesion molecule, MMP Matrix metalloprotein
  2. aContinuous normally distributed variables (data presented as mean and SD) were analyzed with independent-sample t-test. Continuous non-normally distributed variables (data presented as median and IQR) were analyzed with Mann–Whitney U test (n = 131)