From: TOMM40 genetic variants associated with healthy aging and longevity: a systematic review
Authors | Year | Cohort Ancestry | Study Type | SNPs rs Number and Allele Associated with the Phenotype | TOMM40-Associated Phenotype Summary | |||
---|---|---|---|---|---|---|---|---|
 |  |  |  | PVRL2 | TOMM40 | APOE | APOC1 |  |
Li [49] | 2022 | European | Selected Single SNP | Â | rs2075650-g | Â | Â | Led to less language comprehension network strength in females |
Gui [36] | 2021 | Chinese | Selected Single SNP | N/A | rs2075650-g | N/A | N/A | Increased vulnerability to global cognitive decline due to: smoking, drinking, physical inactivity, obesity, total cholesterol (include LDL), triglycerides, diabetes, and hypertension |
Liu [10] | 2021 | Chinese | SNP Array | N/A | rs2075650-A | N/A | N/A | Increased longevity |
Deters [37] | 2021 | Non-Hispanic Black & Non-Hispanic White | Selected Single SNP | N/A | rs10524523-S | N/A | N/A | Altered age-related global cognition, episodic memory, and visuospatial ability segregated by APOE variant: TOMM40 SNP in APOE ε3/ε3: Faster decline TOMM40 SNP in APOE ε4+: Slower decline |
Lamparello [28] | 2020 | Conducted in the United Statesb | SNP Array | N/A | rs2075650-g | N/A | N/A | Altered inflammation response (increased severity) in age-associated blunt injuries |
Kulminski [38] | 2019 | Caucasian | Selected Multiple SNPs | N/A | rs2075650-A/g | rs429358-C | N/A | Lower BMI |
Yashin [29] | 2018 | Mixed Population (World-Wide) | GWAS | rs73052307-T | rs2075650-A rs71352238-T rs34095326-G rs157582-G | rs769449-G | rs56131196-G | Increased longevity |
Yashin [30] | 2018 | Mixed Population (World-Wide) | GWAS | N/A | rs2075650-A rs8106922-A rs157582-C rs71352238-T | rs405509-G rs769450-G rs769449-G | N/A | Increased longevity |
Arpawong [31] | 2017 | Conducted in the United Statesb | GWAS | N/A | rs71352238-G rs2075650-g rs157582-A | rs769449-a | N/A | Delayed verbal recall in non-AD |
Burggren [39] | 2017 | Conducted in the United Statesb | Selected Single SNP | N/A | rs10524523-L | N/A | N/A | Thinner entorhinal cortex in non-AD |
Shadyab [40] | 2017 | Conducted in the United Statesb | Selected Multiple SNPs | N/A | rs2075650 | rs429358 | rs4420638 | Increased longevity in women |
Lin [41] | 2016 | Chinese | Haplotype | N/A | rs7254892-A rs157580-A rs2075649-A rs2075650-A rs157582-T rs8106922-A rs1160985-T | rs405697-Ga rs439401-Ca rs445925-Aa | N/A | Increased longevity |
Payton [42] | 2016 | European | Selected Single SNP | N/A | rs10524523-S | N/A | N/A | Slower vocabulary ability decline in non-AD |
Wennberg [43] | 2016 | Conducted in the United Statesb | Selected Single SNP | N/A | rs10524523 | N/A | N/A | No association with cortical thinning in non-AD |
Deelen [7] | 2014 | European | GWAS | N/A | rs2075650 | rs4420638-A | N/A | Increased longevity |
Greenbaum [44] | 2014 | Israeli Jewish | Selected Single SNP | N/A | rs10524523-S | N/A | N/A | Better cognition in non-AD |
Lu [45] | 2014 | Chinese | Selected Multiple SNPs | rs12972156-A rs519825-A rs395908-C | rs2075650-A/g | rs405509-A | N/A | Increased longevity |
Ferencz [32] | 2013 | European from Island of Kungsholmen | SNP Array | N/A | rs11556505 rs2075650 | N/A | N/A | No association with hippocampal volume and episodic memory performance in non-AD |
Zhang [35] | 2013 | Conducted in the United Statesb | GWAS | N/A | rs115881343 | rs769449 | N/A | Cognitive decline in non-AD |
Caselli [46] | 2012 | Conducted in the United Statesb | Selected Single SNP | N/A | rs10524523 | N/A | N/A | Age-related memory performance in non-AD |
Guo [33] | 2012 | Mixed Population (World-Wide) | GWAS | N/A | rs2075650-g | N/A | N/A | Low BMI |
Sebastiani [34] | 2012 | Conducted in the United Statesb | GWAS | N/A | rs2075650-A | N/A | N/A | Increased longevity |
Maruszak [47] | 2012 | European | Selected Single SNP | N/A | rs10524523-L | N/A | N/A | Decreased longevity |
Johnson [48] | 2011 | Conducted in the United Statesb | Selected Single SNP | N/A | rs10524523-VL | N/A | N/A | Cognitive decline in non-AD |