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Table 1 Summary of the articles investigating TOMM40 SNPs and aging or longevity

From: TOMM40 genetic variants associated with healthy aging and longevity: a systematic review

Authors

Year

Cohort Ancestry

Study Type

SNPs rs Number and Allele Associated with the Phenotype

TOMM40-Associated Phenotype Summary

    

PVRL2

TOMM40

APOE

APOC1

 

Li [49]

2022

European

Selected Single SNP

 

rs2075650-g

  

Led to less language comprehension network strength in females

Gui [36]

2021

Chinese

Selected Single SNP

N/A

rs2075650-g

N/A

N/A

Increased vulnerability to global cognitive decline due to: smoking, drinking, physical inactivity, obesity, total cholesterol (include LDL), triglycerides, diabetes, and hypertension

Liu [10]

2021

Chinese

SNP Array

N/A

rs2075650-A

N/A

N/A

Increased longevity

Deters [37]

2021

Non-Hispanic Black & Non-Hispanic White

Selected Single SNP

N/A

rs10524523-S

N/A

N/A

Altered age-related global cognition, episodic memory, and visuospatial ability segregated by APOE variant:

TOMM40 SNP in APOE ε3/ε3: Faster decline

TOMM40 SNP in APOE ε4+: Slower decline

Lamparello [28]

2020

Conducted in the United Statesb

SNP Array

N/A

rs2075650-g

N/A

N/A

Altered inflammation response (increased severity) in age-associated blunt injuries

Kulminski [38]

2019

Caucasian

Selected Multiple SNPs

N/A

rs2075650-A/g

rs429358-C

N/A

Lower BMI

Yashin [29]

2018

Mixed

Population (World-Wide)

GWAS

rs73052307-T

rs2075650-A

rs71352238-T

rs34095326-G

rs157582-G

rs769449-G

rs56131196-G

Increased longevity

Yashin [30]

2018

Mixed Population (World-Wide)

GWAS

N/A

rs2075650-A

rs8106922-A

rs157582-C

rs71352238-T

rs405509-G

rs769450-G

rs769449-G

N/A

Increased longevity

Arpawong [31]

2017

Conducted in the United Statesb

GWAS

N/A

rs71352238-G

rs2075650-g

rs157582-A

rs769449-a

N/A

Delayed verbal recall in non-AD

Burggren [39]

2017

Conducted in the United Statesb

Selected Single SNP

N/A

rs10524523-L

N/A

N/A

Thinner entorhinal cortex in non-AD

Shadyab [40]

2017

Conducted in the United Statesb

Selected Multiple SNPs

N/A

rs2075650

rs429358

rs4420638

Increased longevity in women

Lin [41]

2016

Chinese

Haplotype

N/A

rs7254892-A

rs157580-A

rs2075649-A

rs2075650-A

rs157582-T

rs8106922-A

rs1160985-T

rs405697-Ga

rs439401-Ca

rs445925-Aa

N/A

Increased longevity

Payton [42]

2016

European

Selected Single SNP

N/A

rs10524523-S

N/A

N/A

Slower vocabulary ability decline in non-AD

Wennberg [43]

2016

Conducted in the United Statesb

Selected Single SNP

N/A

rs10524523

N/A

N/A

No association with cortical thinning in non-AD

Deelen [7]

2014

European

GWAS

N/A

rs2075650

rs4420638-A

N/A

Increased longevity

Greenbaum [44]

2014

Israeli Jewish

Selected Single SNP

N/A

rs10524523-S

N/A

N/A

Better cognition in non-AD

Lu [45]

2014

Chinese

Selected Multiple SNPs

rs12972156-A

rs519825-A

rs395908-C

rs2075650-A/g

rs405509-A

N/A

Increased longevity

Ferencz [32]

2013

European from Island of Kungsholmen

SNP Array

N/A

rs11556505

rs2075650

N/A

N/A

No association with hippocampal volume and episodic memory performance in non-AD

Zhang [35]

2013

Conducted in the United Statesb

GWAS

N/A

rs115881343

rs769449

N/A

Cognitive decline in non-AD

Caselli [46]

2012

Conducted in the United Statesb

Selected Single SNP

N/A

rs10524523

N/A

N/A

Age-related memory performance in non-AD

Guo [33]

2012

Mixed Population (World-Wide)

GWAS

N/A

rs2075650-g

N/A

N/A

Low BMI

Sebastiani [34]

2012

Conducted in the United Statesb

GWAS

N/A

rs2075650-A

N/A

N/A

Increased longevity

Maruszak [47]

2012

European

Selected Single SNP

N/A

rs10524523-L

N/A

N/A

Decreased longevity

Johnson [48]

2011

Conducted in the United Statesb

Selected Single SNP

N/A

rs10524523-VL

N/A

N/A

Cognitive decline in non-AD

  1. rs#: Accession number for specific SNPs
  2. BMI Body Mass Index
  3. non-AD Non-Alzheimer’s disease patients
  4. N/A Not available
  5. a Located at APOE-to-APOC1 intragenic region
  6. b Studies conducted in the United States with mixed population