Table 1 Comparison of the basic characteristics between the control and Alzheimer’s disease (AD) group
Characteristics | Control group | AD group | P value |
|---|---|---|---|
Age (Median, IQR) | 58 (50,63) | 66 (62,68) |  < 0.001 |
TDI (Median, IQR) | -2.2 (-3.7,0.5) | -2 (-3.6,1.1) | 0.037 |
Gender (n, %) |  |  |  < 0.001 |
  Female | 261,396 (54.2) | 443 (48.2) |  |
  Male | 221,192 (45.8) | 476 (51.8) |  |
Ethnicity (n, %) | Â | Â | 0.003 |
  White people | 437,884 (91) | 849 (92.4) |  |
  Mixed people | 17,807 (3.7) | 43 (4.7) |  |
  Other people | 25,270 (5.3) | 27 (2.9) |  |
Education (n, %) |  |  |  < 0.001 |
 College/University | 157,154 (32.9) | 172 (19.3) |  |
 Other | 320,081 (67.1) | 718 (80.7) |  |
Smoking (n, %) |  |  |  < 0.001 |
 Never | 263,316 (54.8) | 431 (47.4) |  |
 Previous | 167,034 (34.7) | 388 (42.7) |  |
 Current | 50,485 (10.5) | 90 (9.9) |  |
Alcohol (n, %) |  |  |  < 0.001 |
 Never | 20,987 (4.4) | 73 (8) |  |
 Previous | 17,105 (3.5) | 74 (8.1) |  |
 Current | 443,980 (92.1) | 768 (83.9) |  |
Myocardial infarction (n, %) | |||
 No | 462,906 (95.9) | 803 (87.4) |  < 0.001 |
 Yes | 19,682 (4.1) | 116 (12.6) |  |
Stroke (n, %) |  |  |  < 0.001 |
 No | 470,248 (97.4) | 817 (88.9) |  |
 Yes | 12,340 (2.6) | 102 (11.1) |  |
Diabetes (n, %) |  |  |  < 0.001 |
 No | 477,875 (99) | 885 (96.3) |  |
 Yes | 4713 (1) | 34 (3.7) |  |
Hypertension (n, %) |  |  |  < 0.001 |
 No | 334,628 (69.3) | 393 (42.8) |  |
 Yes | 147,960 (30.7) | 526 (57.2) |  |
Sleep duration (Median, IQR) | 7 (7,8) | 7 (7,8) |  < 0.001 |