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Table 4 Stratified analyses of association between Dietary Inflammatory Index and serum klotho concentrations (pg/ml) in NHANES 2007–2016a

From: Association between Dietary Inflammatory Index and serum Klotho concentration among adults in the United States

Variable

Dietary Inflammatory index group, β (95%CI), Quartiles

P for interaction

Quartile 1

Quartile 2

Quartile 3

Quartile 4

P for trend

Age (year)c

     

0.003

 40–56

0

19.12 (-0.48, 38.73)

-3.88 (-24.88, 17.12)

-0.02 (-22.28, 22.24)

0.667

 

 56–80

0

-30.10 (-49.18, -11.02)

-45.72 (-65.20, -26.24)

-32.21 (-52.61, -11.81)

 < 0.001

 

Sex

     

0.094

 Male

0

-1.89 (-18.68, 14.90)

-33.26 (-51.94, -14.59)

-34.18 (-55.38, -12.98)

 < 0.001

 

 Female

0

0.27 (-22.11, 22.65)

-9.46 (-31.78, 12.87)

-0.13 (-22.56, 22.30)

0.808

 

BMI (kg/m2)

     

0.015

 normal (< 25 kg/m2)

0

-25.79 (-53.91, 2.32)

-60.43 (-90.66, -30.21)

-49.89 (-81.59, -18.20)

 < 0.001

 

 overweight (25–29.9 kg/m2)

0

-4.42 (-27.02, 18.18)

-18.79 (-42.72, 5.14)

-6.37 (-32.15, 19.41)

0.346

 

 obesity (> = 30 kg/m2)

0

15.76 (-6.21, 37.73)

1.03 (-21.50, 23.55)

2.37 (-21.07, 25.81)

0.901

 

Physical activity

     

0.09

 Less than moderate

0

-13.04 (-32.90, 6.83)

-23.77 (-43.81, -3.72)

-23.83 (-44.40, -3.26)

0.014

 

 Moderate

0

-30.33 (-77.01, 16.34)

-64.32 (-115.35, -13.29)

18.67 (-33.41, 70.75)

0.901

 

 Vigorous

0

15.11 (-6.26, 36.48)

-12.36 (-35.75, 11.03)

-14.68 (-40.48, 11.12)

0.187

 

CKDb

0

    

0.041

 No

0

-0.74 (-15.61, 14.13)

-31.21 (-46.95, -15.47)

-16.99 (-33.78, -0.21)

0.002

 

 Yes

0

-29.05 (-65.83, 7.73)

3.42 (-33.85, 40.68)

-12.34 (-49.27, 24.58)

0.923

 
  1. 95%CI: 95% Confidence interval
  2. DII quartile ranges: Quartile 1 = -5.18 to -0.16; Quartile 2 = -0.16 to 1.43; Quartile 3 = 1.43 to 2.82; Quartile 4: 2.82 to 5.42
  3. aadjusted for age; sex; Race; Ratio of family income to poverty; BMI; alcohol intake; physical activity; smoking status; eGFR. In each stratification, the model is not adjusted for itself
  4. bchronic kidney disease (CKD) was defined as albumin-to-creatinine ratio (ACR) above 30 mg/g or estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m.2
  5. cthe cutoff value was set by median