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Table 6 Multivariable logistic regression model for in-hospital mortality in patients ≥ 80 years of age hospitalized with COVID-19

From: Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain)

  Model Aa Model Bb Model Cc  
OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value
Wave
 First Ref   Ref - Ref  
 Successive 0.61 (0.53–0.70)  < 0.001 0.58 (0.50–0.68)  < 0.001 0.67 (0.57–0.79)  < 0.001
Age group
 80–84 years Ref   Ref   Ref  
 85–90 years 1.25 (1.09–1.43) 0.001 1.26 (1.10–1.44) 0.001 1.31 (1.25–1.54) 0.001
 90–94 years 1.27 (1.08–1.50) 0.004 1.30 (1.10–1.53) 0.001 1.38 (1.13–1.67) 0.001
  ≥ 95 years 1.41 (1.11–1.87) 0.003 1.47 (1.14–1.90) 0.003 1.56 (1.17–2.09) 0.003
 Sex, male 1.44 (1.28–1.63)  < 0.001 1.41 (1.25–1.59)  < 0.001 1.33 (1.16–1.53)  < 0.001
Acquisition
 Community Ref - Ref - Ref  
 Nosocomial 1.52 (1.21–1.90)  < 0.001 1.54 (1.23–1.94)  < 0.001 1.46 (1.11–1.92)  < 0.001
 Nursing Home 0.71 (0.61–0.84)  < 0.001 0.71 (0.61–0.84)  < 0.001 0.72 (0.61–0.88)  < 0.001
Degree of dependence
 Independent or mild Ref - Ref - Ref  
 Moderate 1.40 (1.21–1.64)  < 0.001 1.42 (1.21–1.63)  < 0.001 1.5 (1–29-1.81)  < 0.001
 Severe 1.63 (1.37–1.94)  < 0.001 1.67 (1.40–2.00)  < 0.001 2.05 (1.67–2.53)  < 0.001
Comorbidities
 CCI 1.07 (1.04–1.10)  < 0.001 1.07 (1.04–1.10)  < 0.001 1.07 (1.03–1.11)  < 0.001
Physical examination
 Oxygen saturation < 94% 2.15 (1.91–2.41)  < 0.001 2.09 (1.87–2.35)  < 0.001 1.58 (1.38–1.81)  < 0.001
 qSOFA score ≥ 2 2.79 (2.38–3.27)  < 0.001 2.09 (1.86–2.25)  < 0.001 2.31 1.92–2.78)  < 0.001
Treatment
 Steroid - - 1.29 (1.13–1.45)  < 0.001 1.29 (1.12–1.50)  < 0.001
 Tocilizumab    1.35 (1.00–1.84) 0.049 1.23 (0.89–1.71) 0.68
 Remdesivir    0.52 (0.34–0.79) 0.002 0.51 (0.32–7.98) 0.509
Laboratory findings
 Lymphocytes (× 103/μL)      1.00 (1.00–1.00)  < 0.001
 Lactate dehydrogenase (U/L)      1.00 (1.00–1.00)  < 0.001
 C-reactive protein (mg/L)      1.00 (1.00–1.00)  < 0.001
  1. CCI Charlson Comorbidity Index, OR Odds ratio, CI Interval confidence, qSOFA quick sequential organ failure assessment; Ref Reference
  2. aModel A. Adjusted for age group, sex, place of acquisition, degree of dependence, baseline Charlson Comorbidity Index, oxygen saturation, and qSOFA score
  3. bModel B. Adjusted for age group; sex; place of acquisition; degree of dependence; baseline Charlson Comorbidity Index; oxygen saturation; qSOFA score; and treatment with steroids, tocilizumab, and remdesivir
  4. cModel C. Adjusted for age group; sex; place of acquisition; degree of dependence; baseline Charlson Comorbidity Index; oxygen saturation; qSOFA score; treatment with steroids, tocilizumab, and remdesivir; and laboratory findings of lymphocytes, lactate dehydrogenase, and C-reactive protein