Table 5 Case-fatality rate (CFR) in patients ≥ 80 years of age hospitalized with COVID-19

Total

 80–84 years

818/2271

33.1

36.0

Ref

 85–90 years

921/2106

37.2

43.7

1.38 (1.22–1.55)

 < 0.001

 90–94 years

538/1185

21.8

45.4

1.47 (1.38–1.70)

 < 0.001

  ≥ 95 years

196/391

7.9

50.1

1.78 (1.43–2.21)

 < 0.001

 Total

2473/5953

100

41.5

First wave

 80–84 years

685/1772

34.2

38.7

Ref

 85–90 years

750/1622

37.4

46.2

1.36 (1.19–1.56)

 < 0.001

 90–94 years

413/864

20.6

47.8

1.45 (1.23–1.71)

 < 0.001

  ≥ 95 years

156/287

7.8

54.4

1.89 (1.47–2.42)

 < 0.001

 Total

2004/4545

100

44.1

Successive waves

 80–84 years

133/499

28.4

26.7

Ref

 85–90 years

171/484

36.5

35.3

1.50 (1.14–1.97)

0.003

 90–94 years

125/321

26.7

38.9

1.75 (1.30–2.37)

 < 0.001

  ≥ 95 years

40/104

8.5

38.5

1.72 1.10–2.67)

0.016

 Total

469/1408

100

33.3

-

Differences between first and successive waves*

95% (CI)*

p value**

 80–84 years

-

-

-

-12.0 (-7.4; -16.4)

 < 0.001

 85–90 years

-

-

-

-10.9 (-5.9; -13.2)

 < 0.001

 90–94 years

-

-

-

-8.9 (-2.5, -15.0)

0.006

  ≥ 95 years

-

-

-

-15.8 (-4.7; -26.3)

 < 0.001

 Total

-

-

-

-10.8 (-7.9; -13.6)

 < 0.001