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Table 5 Case-fatality rate (CFR) in patients ≥ 80 years of age hospitalized with COVID-19

From: Differences in clinical features and mortality in very old unvaccinated patients (≥ 80 years) hospitalized with COVID-19 during the first and successive waves from the multicenter SEMI-COVID-19 Registry (Spain)

  No. of deaths/Total No. of Patients % of total deaths CFR % OR (95% CI) p value
Total
 80–84 years 818/2271 33.1 36.0 Ref  
 85–90 years 921/2106 37.2 43.7 1.38 (1.22–1.55)  < 0.001
 90–94 years 538/1185 21.8 45.4 1.47 (1.38–1.70)  < 0.001
  ≥ 95 years 196/391 7.9 50.1 1.78 (1.43–2.21)  < 0.001
 Total 2473/5953 100 41.5   
First wave
 80–84 years 685/1772 34.2 38.7 Ref  
 85–90 years 750/1622 37.4 46.2 1.36 (1.19–1.56)  < 0.001
 90–94 years 413/864 20.6 47.8 1.45 (1.23–1.71)  < 0.001
  ≥ 95 years 156/287 7.8 54.4 1.89 (1.47–2.42)  < 0.001
 Total 2004/4545 100 44.1   
Successive waves
 80–84 years 133/499 28.4 26.7 Ref  
 85–90 years 171/484 36.5 35.3 1.50 (1.14–1.97) 0.003
 90–94 years 125/321 26.7 38.9 1.75 (1.30–2.37)  < 0.001
  ≥ 95 years 40/104 8.5 38.5 1.72 1.10–2.67) 0.016
 Total 469/1408 100 33.3 -  
Differences between first and successive waves* 95% (CI)* p value**
 80–84 years - - - -12.0 (-7.4; -16.4)  < 0.001
 85–90 years - - - -10.9 (-5.9; -13.2)  < 0.001
 90–94 years - - - -8.9 (-2.5, -15.0) 0.006
  ≥ 95 years - - - -15.8 (-4.7; -26.3)  < 0.001
 Total - - - -10.8 (-7.9; -13.6)  < 0.001
  1. *The confidence intervals for differences between CFR in the first wave and successive waves were calculated using the methods of Newcombe et al. ** Significance of differences between the first and successive wave was calculated using the two proportion z-test
  2. OR Odds ratio, CI confidence interval
  3. Statistically significant differences are indicated in bold