Table 2 Characteristics of users and non-users of warfarin on the index date. Comorbidities were defined in relation to the index date
From: Prevalence of oral anticoagulant use among people with and without Alzheimer’s disease
Total: 138 470 | Warfarin Users (20 248) N (%) | P-Value | Non- users of warfarin (118 222) N (%) | P-Value | ||
|---|---|---|---|---|---|---|
People with AD 10 777 (53.2) | People without AD 9 471 (46.8) | People with AD 57 832 (48.9) | People without AD 60 390 (51.1) | |||
Gender | 0.007 | 0.057 | ||||
Women, n (%) | 6 438 (59.7) | 5 834 (61.6) | 38 281 (66.2) | 39 657 (65.7) | ||
Men, n (%) | 4 339 (40.3) | 3 637 (38.4) | 19 551 (33.8) | 20 733 (34.3) | ||
Age (y), mean ± SD | 81.8 ± 5.6 | 82.1 ± 5.6 | 0.0015 | 79.7 ± 7.3 | 79.7 ± 7.2 | 0.72 |
Occupational social class | 0.011 | < 0.001 | ||||
Managerial/Professional | 2 051 (19.0) | 1 793 (18.9) | 12 278 (21.2) | 13 266 (22.0) | ||
Office | 742 (6.9) | 692 (7.3) | 5 051 (8.7) | 5 183 (8.6) | ||
Farming/Forestry | 2 372 (22.0) | 2 186 (23.1) | 10 693 (18.5) | 11 418 (18.9) | ||
Sales/Industrial/Cleaning | 4 686 (43.5) | 3 911 (41.3) | 24 517 (42.4) | 23 270 (38.5) | ||
Unknown | 926 (8.6) | 889 (9.4) | 5 293 (9.2) | 7 253 (12.0) | ||
Comorbidity | ||||||
Atrial fibrillation | < 0.001 | < 0.001 | ||||
< 6 months before | 2 272 (21.1) | 1 376 (14.5) | 990 (1.7) | 544 (0.9) | ||
6–12 months before | 684 (6.3) | 620 (6.5) | 318 (0.5) | 274 (0.5) | ||
More than 1 year before | 3 895 (36.1) | 3 856 (40.7) | 2 052 (3.5) | 1 880 (3.1) | ||
Coronary artery bypass grafting | 0.001 | 0.003 | ||||
< 6 months before | 19 (0.2) | 45 (0.5) | 27 (0.05) | 55 (0.1) | ||
6–12 months before | 19 (0.2) | 16 (0.2) | 31 (0.1) | 49 (0.1) | ||
Percutaneous coronary intervention | 0.056 | 0.001 | ||||
< 6 months before | 28 (0.3) | 34 (0.4) | 141 (0.2) | 205 (0.3) | ||
6–12 months before | 19 (0.2) | 30 (0.3) | 86 (0.2) | 119 (0.2) | ||
Ischemic stroke | 0.050 | < 0.001 | ||||
< 6 months before | 278 (2.6) | 196 (2.1) | 632 (1.1) | 403 (0.7) | ||
6–12 months before | 133 (1.2) | 110 (1.2) | 248 (0.4) | 203 (0.3) | ||
Pulmonary embolism | 0.903 | 0.018 | ||||
< 6 months before | 111 (1.0) | 99 (1.1) | 50 (0.1) | 31 (0.1) | ||
6–12 months before | 50 (0.5) | 48 (0.5) | 23 (0.04) | 37 (0.1) | ||
Deep venous thrombosis | 0.094 | 0.172 | ||||
< 6 months before | 104 (1.0) | 65 (0.7) | 52 (0.1) | 37 (0.1) | ||
6–12 months before | 30 (0.3) | 27 (0.3) | 35 (0.1) | 32 (0.1) | ||
Hemorrhagic stroke | N.Aa | 0.146 | ||||
< 6 months before | -b | -b | 17 (0.03) | 10 (0.02) | ||
6–12 months before | -b | -b | -b | 9 (0.01) | ||