From: Improving individualized prescription in patients with multimorbidity through medication review
Pharmacological data | Previous MR | Post-MR | Difference | P | |
---|---|---|---|---|---|
Number of medications, mean [sd] | |||||
All patients | 8.13 (3.94) | 6.67 (3.72) | -1,45 (1,97) | < 0.001 | |
Sex | Men | 8.43 (3.57) | 6.98 (3.68) | -1,45 (1,94) | < 0.001 |
Women | 7.95 (4.10) | 6.50 (3.74) | -1,45 (1,99) | < 0.001 | |
Frailty degree | No frailty: 0–0.19 | 7.19 (4.50) | 6.65 (3.85) | -0,54 (2,34) | > 0.05 |
Mild frailty: 0.20–0.35 | 7.67 (3.48) | 6.79 (3.27) | -0,88 (1,82) | < 0.001 | |
Moderate frailty: 0.36–0.50 | 8.18 (4.16) | 6.79 (4.19) | -1,40 (1,61) | < 0.001 | |
Severe frailty: > 0.50 | 9.18 (3.59) | 6.05 (2.90) | -3,13 (2,12) | < 0.001 | |
Medication regimen complexity index, mean [sd] | |||||
Whole sample | 31.0 (16.2) | 25.1 (15.1) | -5.9 (8.2) | < 0.001 | |
Sex | Men | 31.3 (14.4) | 25.0 (14.3) | -6.3 (7.6) | < 0.001 |
Women | 30.9 (17.1) | 25.2 (15.4) | -5.7 (8.5) | < 0.001 | |
Frailty degree | No frailty: 0–0.19 | 27.2 (18.6) | 25.6 (15.4) | -1.6 (10.5) | > 0.05 |
Mild frailty: 0.20–0.35 | 28.7 (14.1) | 24.8 (13.1) | -3.9 (7.7) | 0.002 | |
Moderate frailty: 0.36–0.50 | 31.6 (17.4) | 25.9 (17.1) | -5.7 (6.6) | < 0.001 | |
Severe frailty: > 0.50 | 35.5 (14.5) | 23.1 (11.9) | -12.4 (9.1) | < 0.001 | |
Drug burden index, mean [sd] | |||||
Whole sample | 1.19 (0.82) | 1.09 (0.82) | -0.10 (0.35) | < 0.001 | |
Sex | Men | 1.14 (0.90) | 1.00 (0.86) | -0.14 (0.38) | < 0.001 |
Women | 1.22 (0.78) | 1.13 (0.80) | -0.09 (0.34) | < 0.001 | |
Frailty degree | No frailty: 0–0.19 | 0.47 (0.53) | 0.45 (0.44) | -0.02 (0.28) | 0.794 |
Mild frailty: 0.20–0.35 | 0.84 (0.65) | 0.78 (0.65) | -0.06 (0.32) | 0.083 | |
Moderate frailty: 0.36–0.50 | 1.40 (0.84) | 1.27 (0.89) | -0.13 (0.38) | < 0.001 | |
Severe frailty: > 0.50 | 1.58 (0.73) | 1.43 (0.72) | -0.15 (0.33) | 0.002 | |
Monthly drug expenditure, median (Q1;Q3) | |||||
All patients | 57.61 (27.01;116.54) | 45.72 (20.32;99.26) | -4.81 (-16.5;0) | < 0.001 | |
Sex | Men | 78.69 (33.71;135.32) | 66.19 (25.08;121.42) | -5.53 (-19.1;0) | < 0.001 |
Women | 50.59 (23.06;107.00) | 41.55 (18.36;93.37) | -4.72 (-13.9;0) | < 0.001 | |
Frailty degree | No frailty: 0–0.19 | 32.48 (15.89;84.40) | 49.29 (11.32;85.87) | -0.59 (-4.5;8.8) | 0.935 |
Mild frailty: 0.20–0.35 | 50.07 (21.63;100.11) | 43.45 (19.90;99.26) | -2.14 (-9.98;0) | 0.040 | |
Moderate frailty: 0.36–0.50 | 68.77 (27.90;121.13) | 48.17 (20.25;107.97) | -5.97 (-16.9;0) | < 0.001 | |
Severe frailty: > 0.50 | 63.21 (38.25;137.53) | 47.86 (25.93;93.06) | -11.3(-22.33;3.69) | < 0.001 |