| Model 1†| Model 2 (n = 967) | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Odds ratio for prefrailty vs robustness (95% CI) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for frailty vs robustness (95% CI) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for prefrailty vs robustness (95% CI) | Odds ratio per standard deviation increase (95% confidence interval) | p | Odds ratio for frailty vs robustness (95% CI) | Odds ratio per standard deviation increase (95% confidence interval) | p | |
Inflammatory biomarkers | ||||||||||||
 log CRP | 1.22 (1.07–1.39) | 1.26 (1.08–1.46) | 0.003 | 1.37 (1.14–1.66) | 1.47 (1.18–1.82) | 0.001 | 1.05 (0.91–1.22) | 1.06 (0.89–1.27) | 0.49 | 1.13 (0.90–1.42) | 1.15 (0.88–1.51) | 0.30 |
 log IL-6 | 1.68 (1.35–2.09) | 1.46 (1.24–1.70) | < 0.0001 | 2.26 (1.66–3.09) | 1.81 (1.46–2.25) | < 0.0001 | 1.52 (1.18–1.95) | 1.35 (1.13–1.63) | 0.001 | 2.02 (1.38–2.95) | 1.67 (1.26–2.20) | 0.0003 |
Coagulation biomarkers | ||||||||||||
 log tPA | 1.36 (0.96–1.91) | 1.14 (0.98–1.33) | 0.08 | 2.03 (1.22–3.36) | 1.36 (1.09–1.70) | 0.006 | 1.32 (0.91–1.91) | 1.13 (0.96–1.33) | 0.15 | 1.68 (0.94–3.02) | 1.26 (0.97–1.62) | 0.08 |
 log D-dimer | 1.24 (0.96–1.60) | 1.14 (0.98–1.33) | 0.09 | 1.23 (0.85–1.78) | 1.13 (0.91–1.42) | 0.27 | – | |||||
Endothelial biomarkers | ||||||||||||
 log vWF | 1.44 (1.05–1.96) | 1.19 (1.03–1.37) | 0.02 | 1.73 (1.09–2.75) | 1.33 (1.07–1.64) | 0.02 | 1.27 (0.91–1.77) | 1.12 (0.96–1.31) | 0.15 | 1.40 (0.83–2.38) | 1.18 (0.91–1.51) | 0.21 |
Cardiac biomarkers | ||||||||||||
 log hs-cTnT | 1.33 (1.05–1.68) | 1.22 (1.04–1.43) | 0.02 | 2.25 (1.54–3.29) | 1.76 (1.35–2.29) | < 0.0001 | 1.13 (0.90–1.42) | 1.13 (0.95–1.35) | 0.18 | 1.95 (1.24–3.05) | 1.59 (1.16–2.18) | 0.004 |
 log NT-proBNP | 1.13 (1.01–1.27) | 1.17 (1.01–1.36) | 0.03 | 1.26 (1.06–1.15) | 1.36 (1.08–1.71) | 0.008 | 1.08 (0.95–1.22) | 1.10 (0.93–1.30) | 0.27 | 1.14 (0.94–1.40) | 1.19 (0.92–1.54) | 0.19 |
Imaging markers | ||||||||||||
 CIMT | 1.12 (0.44–2.88) | 1.02 (0.88–1.18) | 0.82 | 3.10 (0.78–12.34) | 1.19 (0.96–1.48) | 0.11 | – | |||||
 cfPWV | 1.16 (1.05–1.27) | 1.27 (1.09–1.49) | 0.003 | 1.11 (0.96–1.29) | 1.19 (0.93–1.53) | 0.16 | 1.12 (1.02–1.24) | 1.21 (1.03–1.44) | 0.02 | 1.04 (0.88–1.23) | 1.07 (0.81–1.40) | 0.64 |
 DC | 0.96 (0.92–0.99) | 0.83 (0.71–0.96) | 0.01 | 0.92 (0.86–0.98) | 0.70 (0.54–0.90) | 0.006 | 0.98 (0.94–1.02) | 0.90 (0.76–1.07) | 0.24 | 0.92 (0.86–0.99) | 0.71 (0.53–0.95) | 0.02 |
 ABPI < 0.9 (vs ABPI 0.9–1.4) | 1.33 (0.93–1.90) | – | 0.12 | 1.70 (1.00–2.89) | – | 0.05 | – | |||||
 ABPI > 1.4 (vs ABPI 0.9–1.4) | 0.61 (0.24–1.55) | – | 0.30 | 0.71 (0.14–3.65) | – | 0.68 |