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Table 2 Estimates of the Direct and Indirect effects of Famine Exposure on Stroke in CHARLS, 2011–2015

From: Early-life exposure to Chinese famine and stroke risk in mid- to late life: the mediating roles of cognitive function and depression

Mediators Fetally exposed vs Unexposed Childhood-exposed vs Unexposed Adolescence/adulthood-exposed vs Unexposed
β 95% CI β 95% CI β 95% CI
Cognitive function (M1) a
 NDE 0.75* 0.20, 1.57 0.64* 0.23, 1.29 1.50* 1.24, 2.16
 NIE 0.02* 0.01, 0.04 0.06* 0.01, 0.10 0.11* 0.01, 0.20
Cognitive function (M1) and depression (M2) b
 NDE 0.76* 0.26, 1.60 0.58* 0.02, 1.20 1.45* 1.00, 2.16
 NIE through M1 0.02* 0.01, 0.05 0.05* 0.02, 0.11 0.11* 0.04, 0.21
 NIE through M2 0.12 −0.03, 0.32 0.28* 0.13, 0.51 0.44* 0.22, 0.70
  1. CI confidence interval, NDE natural direct effects, NIE natural indirect effects
  2. a Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, depression, hypertension, dyslipidemia, and diabetes
  3. b Stabilized weights accounted for age, sex, ethnicity, type of residence, childhood economic/health status, marital status, educational level, income, smoking, drinking, body mass index, hypertension, dyslipidemia, and diabetes
  4. *p < .05