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Table 2 Interactiona between the most frequent ASVs (p < 0.05) and analyzed variables

From: Gut microbiota alterations in critically ill older patients: a multicenter study

Variable Groupsa ASVS associated Top ASVs associated p-value Adjusted p-value
Gender Male/Female 16 Lactobacillus 0.0002 0.4902 (2.87)
Ezakiella 0.0037 0.0186 (−1.12)
Oscillibacter 0.0050 0.9653 (0.96)
Eisenbergiella 0.0080 0.6948 (1.21)
Desulfovibrio 0.0091 0.8548 (−0.16)
Discharge condition Dead/Alive 11 Ruminococcaceae UCG 004 0.0014 0.3616 (1.45)
GCA 900066575 0.0021 0.8945 (0.73)
CAG 352 0.0109 0.8616 (0.43)
Brachybacterium 0.0201 0.8327 (0.31)
Ruminococcus gauvreauii 0.0244 0.9143 (0.33)
BMI Adequate/Malnutrition 10 Gallicola 0.0002 0.3271 (1.62)
W5053 0.0009 0.1710 (2.02)
Ezakiella 0.0012 0.1376 (2.30)
Corynebacterium 0.0048 0.258 (1.38)
Elusimicrobium 0.0060 0.3721 (1.02)
ICU stay (days) High/Medium 7 Catenibacterium 0.0084 0.517 (−1.00)
Candidatus.Soleaferrea 0.0156 0.3882 (−1.24)
Prevotella 1 0.0228 0.2848 (−0.98)
Ruminiclostridium 9 0.0263 0.6419 (0.70)
Coriobacteriaceae UCG 003 0.0278 0.3588 (−0.27)
Age group (years) >60 / <60 6 Murdochiella 0.0017 0.0033 (2.05)
Escherichia-Shigella 0.0037 0.005 (−1.87)
Megasphaera 0.0059 0.0095 (2.08)
Peptoniphilus 0.0087 0.0207 (0.37)
Hungatella 0.0112 0.0259 (−0.67)
Ezakiella 0.0199 0.0186 (1.47)
Antibiotics Yes/No 5 Desulfovibrio 0.0163 0.8548 (0.43)
Aggregatibacter 0.0324 0.1946 (0.36)
Ruminococcaceae NK4A214 0.0452 0.1229 (−0.12)
Filifactor 0.0459 0.3059 (0.68)
Victivallis 0.0463 0.6807 (0.89)
  1. aLinear mixed model and adjustment by interactions. The reference group for the comparison is highlighted in bold. The most representative ASVs associated with each variable included in the model are shown; after adjusting for all factors, the last column shows the p-value and in parentheses the sense of the interaction