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Table 2 Interactiona between the most frequent ASVs (p < 0.05) and analyzed variables

From: Gut microbiota alterations in critically ill older patients: a multicenter study

Variable

Groupsa

ASVS associated

Top ASVs associated

p-value

Adjusted p-value

Gender

Male/Female

16

Lactobacillus

0.0002

0.4902 (2.87)

Ezakiella

0.0037

0.0186 (−1.12)

Oscillibacter

0.0050

0.9653 (0.96)

Eisenbergiella

0.0080

0.6948 (1.21)

Desulfovibrio

0.0091

0.8548 (−0.16)

Discharge condition

Dead/Alive

11

Ruminococcaceae UCG 004

0.0014

0.3616 (1.45)

GCA 900066575

0.0021

0.8945 (0.73)

CAG 352

0.0109

0.8616 (0.43)

Brachybacterium

0.0201

0.8327 (0.31)

Ruminococcus gauvreauii

0.0244

0.9143 (0.33)

BMI

Adequate/Malnutrition

10

Gallicola

0.0002

0.3271 (1.62)

W5053

0.0009

0.1710 (2.02)

Ezakiella

0.0012

0.1376 (2.30)

Corynebacterium

0.0048

0.258 (1.38)

Elusimicrobium

0.0060

0.3721 (1.02)

ICU stay (days)

High/Medium

7

Catenibacterium

0.0084

0.517 (−1.00)

Candidatus.Soleaferrea

0.0156

0.3882 (−1.24)

Prevotella 1

0.0228

0.2848 (−0.98)

Ruminiclostridium 9

0.0263

0.6419 (0.70)

Coriobacteriaceae UCG 003

0.0278

0.3588 (−0.27)

Age group (years)

>60 / <60

6

Murdochiella

0.0017

0.0033 (2.05)

Escherichia-Shigella

0.0037

0.005 (−1.87)

Megasphaera

0.0059

0.0095 (2.08)

Peptoniphilus

0.0087

0.0207 (0.37)

Hungatella

0.0112

0.0259 (−0.67)

Ezakiella

0.0199

0.0186 (1.47)

Antibiotics

Yes/No

5

Desulfovibrio

0.0163

0.8548 (0.43)

Aggregatibacter

0.0324

0.1946 (0.36)

Ruminococcaceae NK4A214

0.0452

0.1229 (−0.12)

Filifactor

0.0459

0.3059 (0.68)

Victivallis

0.0463

0.6807 (0.89)

  1. aLinear mixed model and adjustment by interactions. The reference group for the comparison is highlighted in bold. The most representative ASVs associated with each variable included in the model are shown; after adjusting for all factors, the last column shows the p-value and in parentheses the sense of the interaction