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Table 2 Adjusted HRs (95% CI) for the association of baseline (1991–1993) hs-cTnT and NT-proBNP with incident frailty

From: Subclinical cardiovascular disease and frailty risk: the atherosclerosis risk in communities study

Variable

Hs-CTnT

(≥14 vs. < 14 ng/L)

NT-proBNP

(≥100 vs. < 100 pg/mL)

NT-proBNP

(≥300 vs. < 300 pg/mL)

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

Unadjusted

2.569 (1.532–4.310)

< 0.001

1.903 (1.518–2.386)

< 0.001

2.676 (1.505–4.760)

< 0.001

Model 1

2.156 (1.254–3.708)

0.005

1.643 (1.282–2.105)

< 0.001

2.233 (1.244–4.011)

0.007

Model 2

2.127 (1.129–4.010)

0.020

1.330 (1.007–1.756)

0.045

2.614 (1.283–5.327)

0.008

  1. Model 1: adjusted by age, sex, center-race, education (<high school, high school, or > high school), smoking (never, former, current), drinking (never, former, current), body mass index, systolic blood pressure, heart rate, total cholesterol, triglycerides
  2. Model 2: adjusted by model 1 plus cognition Z score, hypertension, diabetes, and cancer
  3. hs-CTnT high-sensitive cardiac troponin T, NT-proBNP N-terminal pro-B-type natriuretic peptide, HR hazard ratio, CI confidence interval