PPI Class | 2013 (n = 28,844,629) | 2014 (n = 30,684,148) | 2015 (n = 32,313,123) | 2016 (n = 33,891,805) | 2017 (n = 35,372,145) | 2018 (n = 36,932,602) | 2019 (n = 38,553,139) |
---|---|---|---|---|---|---|---|
Dexlansoprazole | 226,986 (0.8%) | 225,310 (0.7%) | 232,998 (0.7%) | 233,815 (0.7%) | 223,256 (0.6%) | 211,981 (0.6%) | 201,243 (0.5%) |
Esomeprazole | 1,111,550 (3.9%) | 1,061,160 (3.5%) | 1,076,591 (3.3%) | 916,632 (2.7%) | 797,721 (2.3%) | 688,701 (1.9%) | 672,584 (1.7%) |
Lansoprazole | 387,702 (1.3%) | 380,258 (1.2%) | 364,983 (1.1%) | 300,835 (0.9%) | 244,572 (0.7%) | 225,696 (0.6%) | 230,987 (0.6%) |
Omeprazole | 5,108,489 (17.7%) | 5,395,876 (17.6%) | 5,599,523 (17.3%) | 5,671,998 (16.7%) | 5,588,075 (15.8%) | 5,555,228 (15.0%) | 5,649,420 (14.7%) |
Pantoprazole | 1,758,007 (6.1%) | 2,146,790 (7.0%) | 2,450,771 (7.6%) | 2,738,089 (8.1%) | 3,076,216 (8.7%) | 3,407,091 (9.2%) | 3,781,609 (9.8%) |
Rabeprazole | 75,443 (0.3%) | 61,212 (0.2%) | 54,968 (0.2%) | 52,534 (0.2%) | 49,292 (0.1%) | 48,827 (0.1%) | 50,459 (0.1%) |
Totalb | 8,668,177 (30.1%) | 9,270,606 (30.2%) | 9,779,834 (30.3%) | 9,913,903 (29.3%) | 9,979,132 (28.2%) | 10,137,524 (27.4%) | 10,586,302 (27.5%) |
Benzodiazepines | |||||||
 Alprazolam | 1,786,661 (6.2%) | 1,865,302 (6.1%) | 1,980,676 (6.1%) | 2,009,077 (5.9%) | 2,000,549 (5.7%) | 1,965,284 (5.3%) | 1,905,324 (4.9%) |
 Chlordiazepoxide | 31,937 (0.1%) | 27,715 (< 0.1%) | 25,178 (< 0.1%) | 29,595 (< 0.1%) | 30,014 (< 0.1%) | 26,637 (< 0.1%) | 25,674 (< 0.1%) |
 Clonazepam | 752,162 (2.6%) | 813,472 (2.7%) | 844,327 (2.6%) | 871,342 (2.6%) | 886,423 (2.5%) | 891,142 (2.4%) | 878,711 (2.3%) |
 Clorazepate | 55,888 (0.2%) | 57,288 (0.2%) | 54,743 (0.2%) | 50,707 (0.1%) | 46,122 (0.1%) | 40,986 (0.1%) | 34,705 (< 0.1%) |
 Diazepam | 664,643 (2.3%) | 684,480 (2.2%) | 679,446 (2.1%) | 694,963 (2.1%) | 697,061 (2.0%) | 687,401 (1.9%) | 671,488 (1.7%) |
 Estazolam | 10,435 (< 0.1%) | 9439 (< 0.1%) | 9190 (< 0.1%) | 8651 (< 0.1%) | 8307 (< 0.1%) | 8300 (< 0.1%) | 8567 (< 0.1%) |
 Eszopiclone | 105,064 (0.4%) | 139,817 (0.5%) | 85,005 (0.3%) | 76,631 (0.2%) | 78,527 (0.2%) | 81,222 (0.2%) | 79,400 (0.2%) |
 Flurazepam | 14,508 (< 0.1%) | 10,050 (< 0.1%) | 8148 (< 0.1%) | 6463 (< 0.1%) | 5075 (< 0.1%) | 4731 (< 0.1%) | 3359 (< 0.1%) |
 Lorazepam | 1,617,143 (5.6%) | 1,642,220 (5.4%) | 1,700,107 (5.3%) | 1,709,125 (5.0%) | 1,667,926 (4.7%) | 1,595,208 (4.3%) | 1,531,912 (4.0%) |
 Oxazepam | 21,148 (< 0.1%) | 18,241 (< 0.1%) | 15,736 (< 0.1%) | 13,899 (< 0.1%) | 12,134 (< 0.1%) | 10,866 (< 0.1%) | 9482 (< 0.1%) |
 Temazepam | 524,470 (1.8%) | 543,168 (1.7%) | 557,689 (1.7%) | 523,224 (1.5%) | 480,709 (1.4%) | 462,935 (1.3%) | 419,709 (1.1%) |
 Triazolam | 48,416 (0.2%) | 35,747 (0.1%) | 32,590 (0.1%) | 28,584 (< 0.1%) | 26,591 (< 0.1%) | 26,758 (< 0.1%) | 27,611 (< 0.1%) |
 Zolpidem | 1,758,215 (6.1%) | 1,608,998 (5.2%) | 1,449,947 (4.5%) | 1,288,142 (3.8%) | 1,202,397 (3.4%) | 1,185,920 (3.2%) | 1,140,302 (3.0%) |
Totalb | 7,390,690 (25.6%) | 7,455,937 (24.3%) | 7,442,782 (23.0%) | 7,310,403 (21.6%) | 7,141,835 (20.2%) | 6,987,390 (18.9%) | 6,736,244 (17.5%) |
Antipsychotics | |||||||
 Amoxapine | 1555 (< 0.1%) | 1527 (< 0.1%) | 1439 (< 0.1%) | 1383 (< 0.1%) | 1250 (< 0.1%) | 611(< 0.1%) | 569 (< 0.1%) |
 Aripiprazole | 126,298 (0.4%) | 131,256 (0.4%) | 196,453 (0.6%) | 155,139 (0.5%) | 165,097 (0.5%) | 187,750 (0.5%) | 213,379 (0.6%) |
 Asenapine | 3586 (< 0.1%) | 3620 (< 0.1%) | 3636 (< 0.1%) | 3639 (< 0.1%) | 3388 (< 0.1%) | 3220 (< 0.1%) | 3141 (< 0.1%) |
 Chlorpromazine | 21,011 (< 0.1%) | 20,943 (< 0.1%) | 20,062 (< 0.1%) | 19,113 (< 0.1%) | 18,950 (< 0.1%) | 18,362 (< 0.1%) | 17,757 (< 0.1%) |
 Clozapine | 8,813 (< 0.1%) | 9,362 (< 0.1%) | 10,123 (< 0.1%) | 10,730 (< 0.1%) | 11,464 (< 0.1%) | 12,278 (< 0.1%) | 13,004 (< 0.1%) |
 Haloperidol | 98,486 (0.3%) | 94,136 (0.3%) | 89,010 (0.3%) | 83,392 (0.2%) | 78,850 (0.2%) | 72,109 (0.2%) | 46.401 (0.1%) |
 Iloperidone | 1337 (< 0.1%) | 1329 (< 0.1%) | 1183 (< 0.1%) | 976 (< 0.1%) | 989 (< 0.1%) | 1039 (< 0.1%) | 1011 (< 0.1%) |
 Loxapine | 3214 (< 0.1%) | 3341 (< 0.1%) | 3277 (< 0.1%) | 3318 (< 0.1%) | 3295 (< 0.1%) | 3348 (< 0.1%) | 3477 (< 0.1%) |
 Olanzapine | 191,485 (0.7%) | 196,381 (0.6%) | 203,320 (0.6%) | 211,627 (0.6%) | 222,829 (0.6%) | 235,154 (0.6%) | 248,824 (0.6%) |
 Paliperidone | 4674 (< 0.1%) | 5226 (< 0.1%) | 7307 (< 0.1%) | 7099 (< 0.1%) | 7107 (< 0.1%) | 7735 (< 0.1%) | 8396 (< 0.1%) |
 Quetiapine | 538,274 (1.9%) | 572,652 (1.9%) | 600,267 (1.9%) | 631,804 (1.9%) | 667,785 (1.9%) | 705,936 (1.9%) | 743,744 (1.9%) |
 Risperidone | 339,875 (1.2%) | 326,341 (1.1%) | 315,664 (1.0%) | 305,413 (0.9%) | 296,788 (0.8%) | 293,081 (0.8%) | 291,000 (0.8%) |
Totalb | 1,338,608 (4.6%) | 1,366,114 (4.5%) | 1,451,741 (4.5%) | 1,433,633 (4.2%) | 1,477,792 (4.2%) | 1,540,623 (4.2%) | 1,590,703 (4.1%) |