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Table 4 The relationship between frailty and overall survival

From: The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review

Study Design Patient (n =) Country Frailty screening tool Frailty Prevalence Timing of assessment Age (Median/ Mean; years) % Male/Female TNM Stage Survival Outcome Measured Mean/Median Follow-up (Years) Comments
Artiles-Armas et al. (2021) [34] Prospective 149 Spain Clinical Frailty Scale 42 (CSHA CFS ≥ 4) Pre-operative 75 64/36 I-IV Overall survival 5 Frailty not associated with reduced survival on UV binary log regression (P = 0.249)
Feliciano et al. (2020) [22] Prospective 691 USA Frailty phenotype 18 (Fried ≥ 3/5 criteria) Pre-operative 63 Female only NR Overall survival 5.8 Frailty associated with OS on MV binary log regression (HR 1.94, 95% CI 1.39–2.69, P < 0.001)
Mima et al. (2020) [35] Retrospective 729 Japan Clinical Frailty Scale 35 (CSHA CFS ≥ 4) Pre-operative NR (46% ≥ 75 years) 53/47 I-III Overall survival 3.5 Frailty associated with OS on MV binary log regression (HR 2.40, 95% CI 1.40–2.99, P < 0.001)
  1. UV Univariate, MV Multivariate, HR Hazard ratio