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Table 3 The reclassification performance and improvement in discrimination by the three aging metrics incorporating cognitive and physical functiona

From: Aging metrics incorporating cognitive and physical function capture mortality risk: results from two prospective cohort studies

Aging metrics Delta C-statistic P value IDI P value NRI P value
CHARLS
 CI-PF 0.008 0.017 0.011 < 0.001 0.211 < 0.001
 FI 0.006 0.130 0.009 < 0.001 0.155 < 0.001
 MCR 0.0003 0.843 0.001 0.035 −0.027 0.441
NHANES
 CI-PF 0.021 < 0.001 0.033 < 0.001 0.568 < 0.001
 FI 0.029 < 0.001 0.043 < 0.001 0.332 < 0.001
 MCR 0.003 0.033 0.007 < 0.001 0.125 < 0.001
  1. IDI integrated discrimination improvement, NRI net reclassification index, CHARLS China Health and Retirement Longitudinal Study, CI-PF cognitive impairment and physical frailty, FI frailty index, MCR Motoric Cognitive Risk syndrome, NHANES National Health and Nutrition Examination Survey
  2. Notes: aWe calculated the IDI and continuous NRI using the R package “PredictABEL”, in comparison to that of the model with age and sex