Table 2 Associations of the three aging metrics incorporating cognitive and physical function with all-cause mortality

OR (95% CI)

OR (95% CI)

CI-PF^a

Normal cognition & non-frailty

Ref

Ref

Cognitive impairment & non-frailty

1.59 (1.29, 1.96)

1.35 (1.08, 1.69)

Normal cognition & frailty

1.88 (1.10, 3.20)

1.69 (0.99, 2.90)

Cognitive impairment & frailty

2.87 (1.74, 4.74)

2.42 (1.46, 4.02)

FI

Non-frail

Ref

Ref

Pre-frail

1.34 (1.08, 1.66)

1.27 (1.02, 1.57)

Frail

1.94 (1.50, 2.50)

1.82 (1.41, 2.35)

MCR

Absence

Ref

Ref

Presence

1.27 (1.00, 1.62)

1.16 (0.91, 1.47)

HR (95% CI)

HR (95% CI)

CI-PF

Normal cognition & non-frailty

Ref

Ref

Cognitive impairment & non-frailty

1.39 (1.25, 1.56)

1.39 (1.23, 1.57)

Normal cognition & frailty

3.16 (2.66, 3.76)

3.09 (2.58, 3.69)

Cognitive impairment & frailty

2.85 (2.26, 3.60)

2.78 (2.19, 3.54)

FI

Non-frail

Ref

Ref

Pre-frail

1.39 (1.21, 1.60)

1.36 (1.18, 1.57)

Frail

2.68 (2.33, 3.10)

2.58 (2.23, 2.98)

MCR

Absence

Ref

Ref

Presence

1.91 (1.58, 2.31)

1.83 (1.51, 2.22)