Differential associations of visual memory with hippocampal subfields in subjective cognitive decline and amnestic mild cognitive impairment

Table 3 Comparison of relative hippocampal subfield volumes in normal controls and patients with SCD and aMCI

Relative volume	NC	SCD	aMCI	F	p value
CA1	4.28 ± 0.06	4.21 ± 0.07	3.97 ± 0.06**†	7.014	0.001
Molecular-layer	3.78 ± 0.05	3.73 ± 0.06	3.48 ± 0.05**†	9.490	< 0.001
Subiculum	2.92 ± 0.05	2.96 ± 0.05	2.70 ± 0.05**†	8.505	< 0.001
Presubiculum	2.00 ± 0.04	2.05 ± 0.04	1.87 ± 0.04†	5.275	0.006
GC-ML-DG	2.02 ± 0.03	1.95 ± 0.03	1.84 ± 0.03**†	10.374	< 0.001
CA4	1.74 ± 0.02	1.70 ± 0.03	1.61 ± 0.02**†	8.792	< 0.001
CA3	1.40 ± 0.02	1.32 ± 0.02	1.28 ± 0.02**	7.192	0.001
Parasubiculum	0.40 ± 0.01	0.42 ± 0.01	0.41 ± 0.01	0.716	0.491
HATA	0.38 ± 0.01	0.37 ± 0.01	0.36 ± 0.01	2.589	0.079

Note: Data are represented as mean ± standard deviation
NC normal control, SCD subjective cognitive decline, aMCI amnestic mild cognitive impairment, CA cornu ammonis, GC-ML-DG Granule cell molecular layer of dentate gyrus, HATA Hippocampal amygdala transition area. Relative hippocampal subfield volumes were calculated by dividing hippocampal subfield volumes by estimated total intracranial volume and multiplying by 10,000. Adjusted for age, sex, and APOE ε4 status
^* compared with NC group, p < 0.05;** compared with NC group, p < 0.01; † compared with SCD group, p < 0.05

ISSN: 1471-2318