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Table 2 Association of prenatal exposure to famine with self-reported cognitive problems compared to individuals born before or conceived after the famine

From: Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age

  

Exposure to famine

 

Born Before

In late gestation

In mid gestation

In early gestation

Conceived after

Question 1: I have some/severe problems with my memory, attention and thinking

Full Cohort: N (%)

41 (22.5)

21 (21.4)

22 (28.6)

15 (30.0)

37 (20.1)

  OR (95% CI) Model 1a

Reference

1.0 (0.6–1.7)

1.5 (0.8–2.6)

1.6 (0.8–3.1)

Reference

  OR (95% CI) Model 2b

Reference

1.1 (0.6–1.9)

1.7 (0.9–2.9)

1.7 (0.9–3.3)

Reference

Women: N (%)

18 (18.8)

16 (33.3)

12 (24.0)

5 (19.2)

16 (18.6)

  OR (95% CI) Model 3c

Reference

2.2 (1.1–4.4)

1.4 (0.7–2.9)

1.0 (0.4–2.9)

Reference

  OR (95% CI) Model 4d

Reference

2.5 (1.2–5.4)

1.6 (0.7–3.4)

1.1 (0.4–3.4)

Reference

Men: N(%)

23 (26.7)

5 (10.0)

10 (37.0)

10 (41.7)

21 (21.4)

  OR (95% CI) Model 3c

Reference

0.4 (0.1–0.9)

1.9 (0.8–4.4)

2.3 (0.9–5.5)

Reference

  OR (95% CI) Model 4d

Reference

0.4 (0.1–1.0)

2.0 (0.8–4.8)

2.2 (0.9–5.7)

Reference

Question 2: I consulted a doctor or other healthcare practitioner for problems with your memory, attention and thinking in the past 12 months

Full Cohort: N (%)

9 (4.9)

8 (8.2)

5 (6.6)

7 (14.0)

9 (4.8)

  OR (95% CI) Model 1a

Reference

1.7 (0.7–4.1)

1.4 (0.5–3.8)

3.2 (1.3–8.1)

Reference

  OR (95% CI) Model 2b

Reference

1.9 (0.8–4.6)

1.3 (0.5–3.8)

2.9 (1.1–7.5)

Reference

Women: N (%)

5 (5.2)

4 (8.3)

4 (8.0)

3 (11.5)

21 (6.8)

  OR (95% CI) Model 3c

Reference

1.6 (0.5–5.3)

1.5 (0.5–5.1)

2.3 (0.6–8.9)

Reference

  OR (95% CI) Model 4d

Reference

1.8 (0.5–6.2)

1.4 (0.4–4.7)

2.4 (0.6–9.7)

Reference

Men: N (%)

4 (4.7)

4 (8.0)

1 (3.8)

4 (16.7)

4 (4.1)

  OR (95% CI) Model 3c

Reference

1.9 (0.6–6.7)

0.9 (0.1–7.4)

4.4 (1.2–16.0)

Reference

  OR (95% CI) Model 4d

Reference

2.6 (0.7–9.5)

1.0 (0.1–8.4)

4.0 (1.0–15.5)

Reference

  1. Significant (p < 0.05) findings are depicted in bold
  2. SES socioeconomic status
  3. aModel 1: Logistic regression model, unadjusted
  4. bModel 2: Logistic regression model, adjusted for sex, birth weight, education and SES
  5. cModel 3: Sex-specific logistic regression model, unadjusted
  6. dModel 4: Sex-specific logistic regression model, adjusted for birth weight, education and SES