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Table 3 Association of genotypes of TP53 codon 72 polymorphism in exon 4 and Intron 3 16 bp duplication polymorphism and their haplotypes with anthropometric, body composition and biochemical parameters

From: Importance of TP53 codon 72 and intron 3 duplication 16 bp polymorphisms and their haplotypes in susceptibility to sarcopenia in Iranian older adults

Variable

Exon 4 codon 72

P value

16-bp insertion/deletion

P value

Haplotypes

P value

Arg/Arg

Arg/Pro

Pro/Pro

 

Ins/Ins + Ins/Del

Del/Del

 

Arg-del

Arg-Ins

Pro-del

Pro-Ins

 

Total Skeletal Muscle Mass, kg

23.50 ± 5

24.170 ± 4.4

25.34 ± 4.7

0.03

24.12 ± 4.23

24.57 ± 5

0.48

23.22 ± 4.7

26.66 ± 7.3

25.46 ± 5

23.92 ± 3.8

0.01

Appendicular Lean Mass, Kg

17.72 ± 4.2

18.36 ± 3.91

19.29 ± 4.02

0.04

18.25 ± 3.53

18.67 ± 4.3

0.44

17.51 ± 4.04

20.10 ± 5.86

19.43 ± 4.3

18.11 ± 3.30

0.01

Total Body Fat Mass, Kg

23.38 ± 8.2

24.92 ± 9.76

24.79 ± 7.7

0.46

24.48 ± 8.67

24.39 ± 8.5

0.93

23.23 ± 23

25.10 ± 12.53

25.15 ± 8.8

24.43 ± 8.42

0.55

Skeletal Muscle Mass Index (SMI), Kg/m2

6.95 ± 0.95

7.06 ± 0.98

7.37 ± 0.84

0.007

7.16 ± 0.85

7.14 ± 0.97

0.91

6.89 ± 0.91

7.57 ± 1.22

7.31 ± 0.98

7.12 ± 0.81

0.02

Handgrip strength (MS), Kg

40.86 ± 19

39.26 ± 15.95

46.74 ± 18.4

0.01

44.84 ± 17.7

41.58 ± 18.2

0.18

40.09 ± 18.95

49.44 ± 19.01

42.56 ± 17.7

44.48 ± 17.72

0.39

Gait Speed (GS), m/s

0.78 ± 0.29

0.78 ± 0.20

0.84 ± 0.19

0.05

0.84 ± 0.20

0.79 ± 0.20

0.64

0.85 ± .0.18

0.80 ± 0.20

0.77 ± 0.24

0.78 ± 0.19

0.22

GLU

109.67 ± 30.54

114.40 ± 40.7

110.83 ± 35.19

0.69

111.13 ± 39.6

111.87 ± 33.76

0.87

111.92 ± 41.06

112.87 ± 25.21

101.33 ± 5.7

110.42 ± 31.75

0.875

Albumin, g/dl

3.94 ± 0.24

3.92 ± 0.23

3.94 ± 0.22

0.77

3.99 ± 0.22

3.91 ± 0.24

0.02

3.93 ± 025

4.10 ± 0.141

3.90 ± 0.23

3.98 ± 0.23

0.06

Creatinine, mg/dl

0.87 ± 0.13

0.94 ± 0.35

0.89 ± 0.15

0.13

0.93 ± 0.36

0.89 ± 0.16

0.29

0.87 ± 0.14

0.87 ± 0.08

0.91 ± 0.17

0.93 ± 0.35

0.47

Calcium

9.31 ± 0.55

9.32 ± 0.66

9.27 ± 0.42

0.78

9.41 ± 0.55

9.25 ± 0.54

0.03

9.28 ± 0.54

9.63 ± 0.69

9.23 ± 0.54

9.39 ± 0.54

0.10

BUN, mg/dl

14.41 ± 4.01

15.95 ± 7.4

14.45 ± 4.89

0.14

15.11 ± 7.29

14.82 ± 4.64

0.70

14.43 ± 4.15

14.17 ± 2.23

15.09 ± 4.9

15.19 ± 7.5

08.35

FBS, mg/dl

99.67 ± 30.54

104.39 ± 40.7

100.82 ± 35.19

0.694

101.86 ± 33.7

101.12 ± 39.60

0.879

100.41 ± 31.75

91.33 ± 5.75

102.86 ± 35.2

101.95 ± 41.06

0.875

Cholesterol, mg/dl

182.04 ± 43.84

178.64 ± 42.6

190.95 ± 43.64

0.157

194.20 ± 44.6

179.54 ± 42.12

0.013

180.88 ± 43.43

195.00 ± 50.54

178.62 ± 41.3

194.14 ± 44.52

0.100

LDL-C, g/dl

100.27 ± 34.80

98.31 ± 33.8

109.37 ± 34.03

0.080

109.45 ± 16.1

100.02 ± 33.49

0.045

99.37 ± 34.25

110.33 ± 42.8

100.46 ± 33.1

109.38 ± 25.85

0.258

HDL-C, mg/dl

53.58 ± 12.95

49.72 ± 12.5

49.74 ± 12.89

0.102

51.94 ± 13.05

50.37 ± 12.79

0.372

53.07 ± 13.15

59.17 ± 9.62

48.49 ± 12.26

51.35 ± 13.16

0.048

Triglyceride, mg/dl

126.78 ± 62.16

154.19 ± 85.1

157.55 ± 74.19

0.020

159.04 ± 86.1

141.53 ± 68.42

0.089

125.84 ± 61.91

137.33 ± 70.07

152.37 ± 72.5

160.80 ± 87.44

0.039

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BMC Geriatrics

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