Table 2 Association of genotypes of TP53 codon 72 polymorphism in exon 4 and Intron 3 16 bp duplication polymorphism and haplotypes with sarcopenia
Polymorphism | Genotype / Haplotype | Controls (n = 189) | Sarcopenia patients (n = 65) | P value | OR (95% CI) | PAdj value (age, sex) | ORAdj (95% CI) |
|---|---|---|---|---|---|---|---|
Codon 72 | Co-Dominant model | ||||||
Arg/Arg | 48 (25.4) | 26 (40%) | - | Reference | - | Reference | |
Arg/Pro | 50 (26.5) | 31(47.7%) | < 0.001 | 0.18 (0.072 – 0.449) | < 0.001 | 0.17 (0.068 – 0.447) | |
Pro/Pro | 91 (48.1) | 8 (12.3%) | 0.750 | 1.11 (0.565 – 2.211) | 0.893 | 1.050 (0.518 – 2.126) | |
Dominant model | |||||||
Arg/Arg | 48 (25.4) | 26 (40%) | - | Reference | - | Reference | |
Arg/Pro + Pro/Pro | 141 (74.6) | 39 (60%) | 0.047 | 0.53 (0.284–0.992) | 0.045 | 0.51 (0.269 -0.986) | |
Recessive model | |||||||
Arg/Arg + Arg/Pro | 98 (51.9) | 57 (87.7%) | - | Reference | - | Reference | |
Pro/Pro | 91 (48.1) | 8 (12.3%) | < 0.001 | 0.15 (0.068 – 0.334) | < 0.001 | 0.14 (0.064—0.337) | |
Allele | Arg | 146 (38.6) | 83 (68%) | ||||
Pro | 232 (61.4) | 39 (32%) | |||||
16-bp duplication | Dominant model | ||||||
Del/Del | 122 (64.6) | 50 (76.9%) | - | Reference | - | Reference | |
Del/Ins + Ins/Ins | 67 (35.4) | 15 (23.1%) | 0.223 | 1.52 (0.775 – 2.982) | 0.311 | 1.42 (0.716 – 2.852) | |
Allele | Del | ||||||
Ins | |||||||
Haplotypes | Arg-Del | 43 (22.8) | 25 (38.5%) | - | Reference | - | Reference |
Pro-Del | 79 (41.8) | 25 (38.5%) | 0.342 | 0.34 (0.038 – 3.114) | 0.210 | 0.36 (0.038 – 3.438) | |
Arg-Ins | 5 (2.6) | 1 (1.5%) | 0.074 | 0.54 (0.279 – 1.061) | 0.043 | 0.48 (0.231 – 1.011) | |
Pro-Ins | 62 (32.8) | 14 (21.5%) | 0.015 | 0.38 (0.181 – 0.831) | 0.022 | 0.47 (0.210 – 1.068) | |