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Table 2 Factors associated with BZRA deprescribing and BZRA cessation: multivariate analysis

From: Current practice in benzodiazepine receptor agonists deprescribing on acute geriatric wards: a cohort study

 

BZRA deprescribing

BZRA cessation

OR [95CI]

p value

OR [95CI]

p value

Demographic data

 Agea

1 [0.9;1.0]

.218

1 [0.9;1.0]

.085

Comorbidities

 CIRS-Ga

1 [1;1.1]

.110

1 [1.0;1.1]

.489

 Depression

1.2 [0.8;1.9]

.365

0.9 [0.5;1.7]

.809

 Delirium

1.2 [0.8;1.8]

.457

1.2 [0.7;2.1]

.474

 Cognitive decline

1.5 [1;2.3]

.066

1 [0.6;1.8]

.971

 Anxiety

1.2 [0.7;2.1]

.437

1 [0.5;2]

.991

 Sleep disorder

1.1 [0.6;2.1]

.780

1.7 [0.7;3.7]

.191

Administrative data

 Admission directly to AGU

1

 

1

 

 Admission through emergency room

1.1 [0.7; 1.9]

.651

0.7 [0.3;1.3]

.256

 Admission from another ward

1.5 [0.8; 2.6]

.193

1 [0.4;2]

.931

 Length of staya

1 [1;1]

.215

1 [1;1]

.116

 Living in a nursing home

1.3 [0.7;2.3]

.592

1.4 [0.6;3.2]

.527

 Discharge to home

1

 

1

 

 Discharge to a nursing home

1.5 [0.8;2.7]

.172

1.4 [0.6;2.9]

.387

 Discharge to another ward

0.8 [0.4;1.4]

.404

0.5 [0.2;1.1]

.124

Medications at admission

 BZRA dosagea

1.2 [1.0;1.4]

.020

0.5 [0.4;0.6]

<.001

 Antipsychotic user

0.5 [0.3;0.8]

.008

0.7 [0.3;1.3]

.236

 Antidepressant user

1.6 [1.1;2.4]

.027

1.4 [0.8;2.5]

.243

Miscellaneous

 Intervention of a clinical pharmacist

1.5 [0.9;2.3]

.162

0.8 [0.4;1.5]

.421

 Identification of a BZRA-related adverse event by the treating physician

4.5 [2.6;8]

<.001

2.4 [1.2;4.5]

.012

  1. CIRS-G Cumulative Illness Rating Scale-Geriatric, OR Odds ratio, 95CI 95% confidence interval
  2. aNumeric variables