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Table 2 Critical appraisal of the 11 studies with the use of Quality Criteria Checklista

From: Is there an association between non-alcoholic fatty liver disease and cognitive function? A systematic review

 

Celikbilek, 2018 [22]

Elliott, 2013 [23]

Felipo, 2012 [24]

Filipovic, 2018 [21]

Seo, 2016 [32]

Takahashi, 2017 [28]

Tarter, 1984 [30]

Tarter, 1987 [31]

Tuttolomondo, 2018 [33]

Weinstein, 2018 [27]

Weinstein, 2019 [29]

Relevance Questions

 1. Would implementing the studied intervention or procedure (if found successful) result in improved outcomes for the patients/clients/population group?

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

NA

 2. Did the authors study an outcome (dependent variable) or topic that the patients/clients/population group would care about?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 3. Is the focus of the intervention or procedure (independent variable) or topic of study a common issue of concern to dietetics practice?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 4. Is the intervention or procedure feasible?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Validity Questions

 1. Was the research question clearly stated?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 2. Was the selection of study subjects/patients free from bias?

Y

Y

Y

Y

Y

Y

N

N

Y

Y

Y

 3. Were study groups comparable or was an appropriate reference standard used?

Y

N

Unclear

Y

Y

Y

N

Y

Y

Y

Y

 4. Were methods of handling losses from the original sample (withdrawals) described?

Y

N

NA

Y

N

N

N

N

NA

NA

Y

 5. Was blinding used to prevent introduction of bias?

Y

Y

Y

Y

Y

Y

Unclear

Y

Y

Y

Y

 6. Was the intervention/treatment regimen/exposure factor, procedure, process or product of interest, and any comparison(s) described in detail? Were intervening factors described?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 7. Were outcomes or condition or status of interest clearly defined and the measurements valid and reliable?

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

Y

 8. Was the statistical analysis appropriate for the study design and type of outcome indicators?

Y

Y

Y

Y

Y

Y

Y

Unclear

Y

Y

Y

 9. Are conclusions supported by results with biases and limitations taken into consideration?

Y

Y

N

Y

Y

Y

N

N

Y

Y

Y

 10. Is bias due to study’s funding or sponsorship unlikely?

Y

Y

Y

Y

Y

Y

Y

N

Y

Y

Y

Overall Ratingb

Positive +

Positive +

Positive +

Positive +

Positive +

Positive +

Positive +

Neutral Ø

Neutral Ø

Positive +

Positive +

  1. aThe Academy of Nutrition and Dietetics Evidence Analysis Library (EAL) and Quality Criteria Checklist was used as the appraisal tools
  2. bAbbreviations: NA Not Applicable. Positive (+) = most of the answers to the validity questions are “Yes” (including criteria 2, 3, 6, and 7 and at least one additional “Yes”). Neutral (Ø) = the answers to the validity criteria questions 2, 3, 6, and 7 do not indicate that study is exceptionally strong. Negative (−) = most (six or more) of the answers to the validity questions are “No”