Sarcopenia and coronary heart disease synergistically increase the risk of new onset depressive symptoms in older adults

Table 2 Association of Co-occurring Sarcopenia and CHD with New onset of Depressive Symptoms

Variables	Normal	CHD alone	Sarcopenia alone	Co-occurring	P-value
The onset depressive symptoms (%)	52(8.2)	29(16.7)^a	12(19.0)^a	10(40.0)^a,b,c	<0.001
Logistic regression analyses odd ratio (95% CI)
Unadjusted	1.00(Reference)	2.24(1.38,3.66)^a	2.64(1.32,5.26)^a	7.47(3.20,17.47)^a,b,c
Adjusted¹	1.00(Reference)	1.78(1.05,3.02)^a	2.79(1.26,6.22)^a	7.19(2.75,18.81)^a,b,c

Notes: CI confidence interval
1 Adjusted for age, sex, BMI, widowed, education, falling history, drinking, MNA-SF, sleep duration, sleep quality, hypotensive drugs, hypoglycemic drugs, cardiovascular drugs, sleep drugs and CCI
^aP < 0.05 versus Normal, ^bP < 0.05 versus CHD alone, ^c P < 0.05 versus Sarcopenia alone

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