Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study

BMC Geriatrics

Table 3 Linear regression analyses between baseline sarcopenic parameters and GM volume changes

		β Estimate	Standardized β	SE	p value
Model 1	1) BMI, kg/m²	−0·13		0·08	0·105
	2) ASM, kg	0·22		0·11	0·048
	3) Handgrip strength^a, kg	2·91		1·24	0·019
Model 2	BMI, kg/m²	−0·22	−0·08	0.09	0·012
	ASM, kg	0·28	0·14	0.13	0·034
	Handgrip strength^a, kg	2·06	0·08	1.33	0·123

Model 1 evaluated the effects of BMI, ASM, and handgrip strength separately in models 1), 2), and 3), respectively. Model 2 considered BMI, ASM and handgrip strength jointly. All models were adjusted for intracranial volume, age, sex, smoking, alcohol, exercise, education, hypertension, heart disease, baseline GM volume, time between dual-energy X-ray absorptiometry and first MRI, and time between MRI scans. GM volume changes were calculated by subtracting baseline brain volumes from follow-up brain volumes
^a Statistical significance was estimated after logarithmic transformation
Abbreviations: ASM appendicular skeletal muscle mass; BMI body mass index; GM gray matter; MRI magnetic resonance imaging

ISSN: 1471-2318