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Table 2 Characteristics of the four subject groups, stratified by FSH

From: A low follicle-stimulating hormone level is a protective factor for non-alcoholic fatty liver disease in older men aged over 80

Variable Q1 Q2 Q3 Q4 P
N 110 110 110 114  
FSH (IU/L) 9.61 (7.40–11.41) 14.82 (13.96–16.94) 25.12 (21.43–32.35) 51.6 (42.85–64.94)  
Age (years) 84 (81–87) 85 (83–89) 85 (83–89) 88 (85–91) < 0.001
BMI (kg/m2) 24.3 ± 3.0 25.0 ± 3.5 23.5 ± 3.4 24.0 ± 3.6 0.020
WC (cm) 91 ± 8 93 ± 8 90 ± 11 90 ± 11 0.014
SBP (mmHg) 137 ± 22 133 ± 22 133 ± 19 134 ± 19 0.425
DBP (mmHg) 71 ± 12 70 ± 12 66 ± 11 70 ± 11 0.030
Diabetes (%) 34.5 36.4 47.3 35.1 0.166
Hypertension (%) 85.5 78.2 89.1 80.7 0.130
Current/ex-smoker (%) 24.5 25.5 25.9 33.3 0.426
High education (%) 87.8 88.9 88.5 63.2 < 0.001
Married status (%) 92.2 94.4 92.7 89.5 0.579
Routine exercisea 44.9 40.0 41.2 42.1 0.912
MNA-SF score 13.0 (11.0–14.0) 13.0 (12.0–14.0) 12.0 (11.0–13.0) 12.0 (10.0–14.0) 0.034
Lipid-lowering drug users (%) 50.9 52.7 58.2 56.1 0.697
Antihypertensive drug users (%) 60 60 70.9 68.4 0.197
TT (nmol/L) 14.7 (8.0–19.5) 13.3 (9.3–18.4) 10.4 (7.9–15.0) 9.3 (6.3–12.6) < 0.001
E2 (pmol/L) 141 (124–174) 153 (119–188) 121 (99–152) 109 (89–143) < 0.001
LH (IU/L) 6.0 (4.7–8.3) 8.5 (6.2–10.5) 12.1 (8.1–17.3) 25.7 (22.3–35.8) < 0.001
HbA1c (%) 5.7 (5.6–6.1) 5.9 (5.4–6.7) 6.0 (5.6–6.5) 5.9 (5.5–6.2) 0.191
FPG (mmol/L) 5.2 (4.6–5.7) 5.1 (4.8–5.8) 5.4 (4.8–6.4) 5.2 (4.8–5.6) 0.373
FINS (pmol/L) 6.4 (4.3–10.5) 8.1 (5.2–11.1) 7.1 (4.0–12.0) 6.8 (4.8–11.3) 0.312
TC (mmol/L) 3.74 (3.22–4.46) 4.06 (3.30–4.70) 4.00 (3.34–4.94) 3.89 (3.39–4.39) 0.143
TG (mmol/L) 0.83 (0.61–1.19) 1.08 (0.81–1.45) 1.04 (0.68–1.36) 1.07 (0.83–1.42) 0.004
LDL-c (mmol/L) 2.00 (1.70–2.47) 2.24 (1.63–2.89) 2.07 (1.71–2.97) 2.03 (1.64–2.60) 0.110
HDL-c (mmol/L) 1.14 (0.92–1.44) 1.10 (0.90–1.22) 1.04 (0.88–1.35) 1.20 (0.97–1.36) 0.115
ALT (U/L) 12 (10–18) 14 (10–20) 13 (8–19) 12 (8–19) 0.389
AST (U/L) 18 (16–22) 20 (17–23) 18 (15–22) 20 (15–23) 0.207
hsCRP (mg/L) 1.35 (0.46–5.58) 1.23 (0.58–2.04) 1.47 (0.58–3.34) 1.40 (0.49–3.64) 0.583
PCT (ng/mL) 0.037 (0.024–0.042) 0.037 (0.026–0.045) 0.036 (0.023–0.50) 0.039 (0.030–0.054) 0.088
  1. Data were summarized as the mean ± standard deviation for normally distributed variables or median (interquartile range) for skewed variables continuous variables or as proportion for categorical variables. The Kruskal–Wallis test and ANOVA were used for continuous variables with a skewed or normal distribution, and the chi-square (χ2) test was used for categorical variables. aRoutine exercise: moderate to strenuous intensity ≥3 times a week
  2. Abbreviations: ALT Alanine aminotransferase, AST Aspartate aminotransferase, BMI body mass index, DBP diastolic blood pressure, E2 estradiol, FINS fasting insulin, FPG fasting plasma glucose, FSH follicle-stimulating hormone, HbA1c hemoglobin A1c, HDL-c high-density lipoprotein cholesterol, hsCRP high sensitive C-reactive protein, LDL-c low-density lipoprotein cholesterol, LH luteinizing hormone, MNA-SF Short-form of Mini Nutritional Assessment, PCT procalcitonin, SBP systolic blood pressure, TC total cholesterol, TG triglyceride, TT total testosterone, WC waist circumference