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Table 1 Characteristics of all 444 subjects according to NAFLD

From: A low follicle-stimulating hormone level is a protective factor for non-alcoholic fatty liver disease in older men aged over 80

 

Non-NAFLD

NAFLD

P

N

336

108

 

Age (years)

86 (83–90)

84 (82–88)

0.006

BMI (kg/m2)

23.6 ± 3.3

26.0 ± 3.0

< 0.001

WC (cm)

89 ± 9

97 ± 8

< 0.001

SBP (mmHg)

134 ± 21

136 ± 19

0.202

DBP (mmHg)

69 ± 12

69 ± 12

0.986

Diabetes (%)

36.9

41.5

0.394

Hypertension (%)

79.8

94.4

< 0.001

Current/ex-smoker (%)

27.6

26.5

0.827

High education (%)

80.0

86.5

0.135

Married status (%)

92.7

90.6

0.481

Routine exercisea (%)

41.3

44.2

0.599

MNA-SF score

12.0 (10.0–13.3)

13.0 (12.0–14.0)

< 0.001

Malnutrition/Nutritional Risk (%)

36.3

13.2

< 0.001

Lipid-lowering drug users (%)

51.2

64.8

0.013

Antihypertensive drug users (%)

61.3

75.9

0.006

TT (nmol/L)

12.9 (8.5–18.4)

9.5 (6.5–11.7)

< 0.001

E2 (pmol/L)

140 (106–167)

113 (83–136)

< 0.001

LH (IU/L)

10.1 (6.8–21)

9.5 (6.5–11.7)

0.568

FSH (IU/L)

17.8 (12.7–35.2)

22.4 (14.2–42.9)

0.025

HbA1c (%)

5.7 (5.5–6.2)

6.2 (5.8–6.8)

< 0.001

FPG (mmol/L)

5.0 (4.7–5.6)

5.6 (5.2–6.5)

< 0.001

FINS (mU/L)

5.9 (4.0–9.4)

11.0 (8.1–14.6)

< 0.001

TC (mmol/L)

3.84 (3.22–4.64)

4.01 (3.52–4.71)

0.086

TG (mmol/L)

0.90 (0.65–1.25)

1.34 (1.05–2.08)

< 0.001

LDL-c (mmol/L)

2.03 (1.64–2.72)

2.33 (1.86–2.79)

0.002

HDL-c (mmol/L)

1.15 (0.94–1.40)

0.96 (0.86–1.19)

< 0.001

ALT (U/L)

12 (9–18)

15 (11–20)

0.004

AST (U/L)

18 (15–22)

19 (17–22)

0.082

hsCRP (mg/L)

1.34 (0.49–4.56)

1.47 (0.81–2.72)

0.555

PCT (ng/mL)

0.036 (0.026–0.047)

0.041 (0.029–0.054)

0.007

  1. Data were summarized as the mean ± standard deviation for normally distributed variables or median (interquartile range) for skewed variables continuous variables or as proportion for categorical variables. For normally distributed variables and skewed variables, the differences were evaluated with the Student’s t-test or Mann–Whitney U-test. The chi-square (χ2) test was used for categorical variables. aRoutine exercise: moderate to strenuous intensity ≥3 times a week
  2. Abbreviations: ALT Alanine aminotransferase, AST Aspartate aminotransferase, BMI body mass index, DBP diastolic blood pressure, E2 estradiol, FINS fasting insulin, FPG fasting plasma glucose, FSH follicle-stimulating hormone, HbA1c hemoglobin A1c, HDL-c high-density lipoprotein cholesterol, hsCRP high sensitive C-reactive protein, LDL-c low-density lipoprotein cholesterol, LH luteinizing hormone, MNA-SF Short-form of Mini Nutritional Assessment, PCT procalcitonin, SBP systolic blood pressure, TC total cholesterol, TG triglyceride, TT total testosterone, WC waist circumference