Cognitive function assessed by Mini-mental state examination and risk of all-cause mortality: a community-based prospective cohort study

Table 2 Cox regression analyses for the association between all-cause mortality and MMSE scores

MMSE Scores	Subjects (No.)	Death (No.), n (%)	HR (95% CI)
MMSE Scores	Subjects (No.)	Death (No.), n (%)	Model 1^a	Model2^b	Model 3^c
Continuous variable
MMSE scores	1854	333 (17.96)	0.88 (0.86, 0.90) ***	0.94 (0.91, 0.96) ***	0.96 (0.93, 0.98) **
Dichotomous variable
MMSE ≥24	1602	245 (15.29)	1(Reference)	1(Reference)	1(Reference)
MMSE < 24	252	88 (34.92)	2.57 (2.01, 3.28) ***	1.70 (1.31, 2.20) ***	1.43 (1.05, 1.95) *
Multi-categorical variable
MMSE 30	468	46 (9.83)	1(Reference)	1(Reference)	1(Reference)
MMSE 27–29	841	130 (15.46)	1.63 (1.17, 2.28) **	1.32 (0.94, 1.85)	1.27 (0.89, 1.82)
MMSE 24–26	293	69 (23.55)	2.60 (1.79, 3.78) ***	1.47 (1.00, 2.15)	1.30 (0.86, 1.99)
MMSE < 24	252	88 (34.92)	4.14 (2.89, 5.91) ***	2.20 (1.51, 3.21) ***	1.79 (1.15, 2.77) **
P for trend			p < 0.001	p < 0.001	0.003

Abbreviation: HR hazard ratio; CI confidence interval
^a adjusted for none
^b adjusted for age and sex
^c adjusted for age, sex, BMI, waistline, SBP, DBP, FPG, TC, HDL, LDL, TG, eGFR, education level, marital status, smoking status, drinking status, CHD, hypertension, diabetes mellitus, stroke, family history of dementia, dyslipidemia, antiplatelet agents, antihypertensive agents, hypoglycemic therapy, lipid-lowering therapy, and ADL impairment
*P < 0.05
**P < 0.01
***P < 0.001

ISSN: 1471-2318