From: Do prescription rates of psychotropic drugs change over three years from nursing home admission?
Prevalence | |||||||||||||||||||||
BL N = 113 (D-); 583 (D+); 696 (T) | 6 m N = 71 (D-); 437 (D+); 508 (T) | 12 m N = 53 (D-); 374 (D+); 427 (T) | 18 m N = 42 (D-); 307 (D+); 349 (T) | 24 m N = 34 (D-); 259 (D+); 293 (T) | 30 m N = 28 (D-); 209 (D+); 237 (T) | 36 m N = 24 (D-); 168 (D+); 192 (T) | |||||||||||||||
Drug category | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T |
Antidepressants | 28.3 | 28.5 | 28.4 | 33.8 | 38.9 | 38.2 | 35.8 | 40.6 | 40.0 | 40.5 | 40.1 | 40.1 | 38.2 | 42.5 | 42.0 | 39.3 | 42.6 | 42.2 | 45.8 | 41.7 | 42.2 |
Atypical antipsychotics | 6.2 | 7.0 | 6.9 | 4.2 | 13.7 | 12.4 | 1.9 | 12.6 | 11.2 | 4.8 | 16.0 | 14.6 | 2.9 | 14.3 | 13.0 | 7.1 | 14.8 | 13.9 | 0 | 16.7 | 14.6 |
Typical antipsychotics | 5.3 | 4.8 | 4.9 | 5.6 | 4.6 | 4.7 | 5.7 | 4.3 | 4.4 | 7.1 | 4.9 | 5.2 | 2.9 | 3.9 | 3.8 | 3.6 | 3.8 | 3.8 | 4.2 | 3.0 | 3.1 |
Any antipsychotic | 10.6 | 11.7 | 11.5 | 8.5 | 18.1 | 16.7 | 7.5 | 16.8 | 15.7 | 11.9 | 20.8 | 19.8 | 5.9 | 17.8 | 16.4 | 10.7 | 18.2 | 17.3 | 4.2 | 19.6 | 17.7 |
Anxiolytics | 16.8 | 15.4 | 15.7 | 23.9 | 20.6 | 21.1 | 28.3 | 21.1 | 22.0 | 33.3 | 23.5 | 24.6 | 29.4 | 21.2 | 22.2 | 21.4 | 19.1 | 19.4 | 29.2 | 19.6 | 20.8 |
Sedatives and hypnotics | 35.4 | 22.5 | 24.6 | 47.9 | 29.7 | 32.3 | 49.1 | 23.5 | 26.7 | 50.0 | 23.1 | 26.4 | 47.1 | 23.6 | 26.3 | 50.0 | 18.7 | 22.4 | 45.8 | 22.6 | 25.5 |
Antidementia drugs | 5.3 | 27.4 | 23.9 | 5.6 | 28.1 | 25.0 | 7.5 | 27.5 | 25.1 | 9.5 | 24.8 | 22.9 | 2.9 | 22.0 | 19.8 | 7.1 | 23.4 | 21.5 | 8.3 | 19.6 | 18.2 |
Cholinesterase inhibitors | 2.7 | 20.2 | 17.4 | 4.2 | 19.5 | 17.3 | 5.7 | 18.4 | 16.9 | 7.1 | 16.3 | 15.2 | 2.9 | 13.1 | 11.9 | 3.6 | 13.9 | 12.7 | 4.2 | 11.9 | 10.9 |
At least one PTDa | 59.3 | 63.0 | 62.4 | 66.2 | 71.6 | 70.9 | 77.4 | 72.2 | 72.8 | 76.2 | 72.6 | 73.1 | 73.5 | 71.8 | 72.0 | 75.0 | 69.4 | 70.0 | 75.0 | 68.5 | 69.3 |
Mean (SD) | |||||||||||||||||||||
Total medication - mean | 7.3 | 5.7 | 6.0 | 8.2 | 6.2 | 6.5 | 7.5 | 6.0 | 6.2 | 7.2 | 5.9 | 6.1 | 7.3 | 6.2 | 6.3 | 7.2 | 6.3 | 6.4 | 7.8 | 6.3 | 6.5 |
(SD) | (3.5) | (3.1) | (3.2) | (3.5) | (3.0) | (3.1) | (3.4) | (3.0) | (3.1) | (3.6) | (3.3) | (3.3) | (3.5) | (3.3) | (3.3) | (3.9) | (3.3) | (3.4) | (3.9) | (3.7) | (3.7) |
Total PTDa - mean | 1.1 | 1.1 | 1.2 | 1.3 | 1.5 | 1.5 | 1.4 | 1.4 | 1.4 | 1.6 | 1.4 | 1.5 | 1.4 | 1.4 | 1.4 | 1.4 | 1.3 | 1.4 | 1.5 | 1.4 | 1.4 |
(SD) | (1.2) | (1.2) | (1.2) | (1.3) | (1.3) | (1.3) | (1.2) | (1.2) | (1.2) | (1.3) | (1.3) | (1.3) | (1.1) | (1.2) | (1.2) | (1.2) | (1.2) | (1.2) | (1.4) | (1.2) | (1.3) |
Incidenceb | |||||||||||||||||||||
BL-6 m N = 71 (D-); 437 (D+); 508 (T) | 6 m-12 m N = 51 (D-); 346 (D+); 397 (T) | 12 m-18 m N = 40 (D-); 298 (D+); 338 (T) | 18 m-24 m N = 30 (D-); 246 (D+); 276 (T) | 24 m-30 m N = 27 (D-); 200 (D+); 227 (T) | 30 m-36 m N = 22 (D-); 156 (D+); 178 (T) | ||||||||||||||||
Drug category | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | |||
Antidepressants | 17.3 | 19.2 | 18.9 | 8.8 | 9.0 | 8.9 | 12.0 | 6.3 | 7.0 | 5.3 | 7.0 | 6.8 | 6.3 | 8.6 | 8.3 | 14.3 | 4.6 | 5.9 | |||
Atypical antipsychotics | 1.5 | 8.9 | 7.8 | 0 | 4.3 | 3.7 | 0 | 4.3 | 3.7 | 3.3 | 2.9 | 3.0 | 7.4 | 3.6 | 4.1 | 0 | 1.6 | 1.3 | |||
Typical antipsychotic | 1.5 | 2.4 | 2.3 | 0 | 1.8 | 1.6 | 2.6 | 2.1 | 2.2 | 0 | 0.4 | 0.4 | 0 | 0 | 0 | 0 | 0 | 0 | |||
Any antipsychotic | 3.1 | 10.5 | 9.4 | 0 | 5.6 | 4.8 | 2.7 | 6.6 | 6.0 | 3.6 | 2.6 | 2.7 | 7.7 | 3.7 | 4.3 | 0 | 0.8 | 0.7 | |||
Anxiolytics | 11.7 | 12.0 | 12.0 | 10.8 | 5.7 | 6.3 | 13.3 | 5.3 | 6.2 | 0 | 5.3 | 4.8 | 0 | 3.9 | 3.4 | 5.9 | 3.2 | 3.5 | |||
Sedatives and hypnotics | 23.8 | 17.0 | 17.7 | 4.2 | 4.3 | 4.3 | 16.7 | 7.0 | 7.8 | 18.8 | 4.8 | 5.9 | 7.7 | 3.2 | 3.6 | 0 | 4.1 | 3.8 | |||
Antidementia drugs | 2.9 | 10.7 | 9.3 | 0 | 3.3 | 2.8 | 0 | 2.8 | 2.4 | 0 | 2.7 | 2.4 | 0 | 2.0 | 1.7 | 0 | 2.5 | 2.1 | |||
Cholinesterase inhibitors | 2.9 | 6.4 | 5.8 | 0 | 2.6 | 2.2 | 0 | 1.7 | 1.4 | 0 | 1.4 | 1.3 | 0 | 1.2 | 1.0 | 0 | 1.5 | 1.3 | |||
Deprescribing ratesb | |||||||||||||||||||||
BL-6 m N = 71 (D-); 437 (D+); 508 (T) | 6 m-12 m N = 51 (D-); 346 (D+); 397 (T) | 12 m-18 m N = 40 (D-); 298 (D+); 338 (T) | 18 m-24 m N = 30 (D-); 246 (D+); 276 (T) | 24 m-30 m N = 27 (D-); 200 (D+); 227 (T) | 30 m-36 m N = 22 (D-); 156 (D+); 178 (T) | ||||||||||||||||
Drug category | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | D- | D+ | T | |||
Antidepressants | 21.1 | 14.6 | 15.4 | 11.8 | 8.2 | 8.6 | 6.7 | 12.9 | 12.2 | 9.1 | 9.7 | 9.6 | 18.2 | 11.9 | 12.6 | 12.5 | 10.1 | 10.4 | |||
Atypical antipsychotics | 33.3 | 27.3 | 27.8 | 0 | 27.3 | 26.7 | 0 | 16.3 | 15.9 | 0 | 25.0 | 25.0 | 0 | 22.6 | 22.6 | 0 | 3.7 | 3.7 | |||
Typical antipsychotics | 25.0 | 60.0 | 55.2 | 0 | 41.2 | 35.0 | 0 | 18.2 | 15.4 | 50.0 | 20.0 | 25.0 | 0 | 0 | 0 | 0 | 16.7 | 14.3 | |||
Any antipsychotic | 33.3 | 31.6 | 31.7 | 0 | 25.0 | 23.4 | 0 | 14.8 | 14.0 | 50.0 | 22.0 | 23.1 | 0 | 18.4 | 17.9 | 0 | 3.0 | 2.9 | |||
Anxiolytics | 9.1 | 35.2 | 31.7 | 28.6 | 13.8 | 16.5 | 0 | 19.7 | 17.3 | 9.1 | 22.8 | 20.6 | 37.5 | 26.7 | 28.3 | 0 | 12.5 | 10.8 | |||
Sedatives and hypnotics | 17.2 | 24.2 | 22.6 | 14.8 | 22.8 | 21.0 | 18.2 | 26.8 | 24.7 | 21.4 | 15.8 | 16.9 | 14.3 | 26.1 | 23.3 | 16.7 | 15.2 | 15.6 | |||
Antidementia drugs | 33.3 | 30.2 | 30.3 | 0 | 17.8 | 17.1 | 0 | 19.0 | 18.4 | 0 | 20.3 | 20.0 | 0 | 10.4 | 10.2 | 0 | 19.4 | 18.4 | |||
Cholinesterase inhibitors | 50.0 | 31.5 | 31.9 | 0 | 23.7 | 22.8 | 0 | 22.4 | 21.7 | 0 | 21.1 | 20.5 | 0 | 14.3 | 13.8 | 0 | 25.0 | 24.0 |