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Table 4 Detailed performance of the five GFR-Estimating Equations

From: Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients

  Bias Precision Accuracy MAE GFR category
Misclassification(%)
Median difference IQR P30(%) RMSE
All Participants(N = 612)
 CKD-EPI 0.795a 16.2 64.9 14.5 10.7 37.4
 LMR −3.015a 13.4 69.9* 13.3 9.79 37.4
 BIS1 −0.050 12.7 73.9** 12.9 9.26 35.3
 FAS −1.765a 13.1 72.4** 12.1 9.48 36.3
 EKFC −1.970a 13.5 69.0* 13.3 9.71 36.9
Participants Aged 65–79 Years(N = 444)
 CKD-EPI 0.290 15.3 65.1 14.2 10.40 38.1
 LMR −3.140a 12.7 69.1* 13.5 9.80 38.3
 BIS1 0.150 12.7 73.0** 13.1 9.33 36.5
 FAS −1.670a 12.7 72.1** 13.2 9.46 37.2
 EKFC −2.180a 13.0 68.9* 13.5 9.68 37.4
Participants Aged ≥80 Years(N = 168)
 CKD-EPI 3.135a 18.0 64.3 15.1 11.30 35.7
 LMR −2.615a 14.2 72.0* 12.9 9.76 35.1
 BIS1 −1.095 13.8 76.2* 12.1 9.11 32.1
 FAS −1.810 13.5 73.2* 12.7 9.54 33.9
 EKFC −1.800a 14.8 69.0 13.0 9.82 35.7
Male(N = 386)
 CKD-EPI 0.665 15.7 68.4 14.2 10.34 36.0
 LMR −3.890a 14.1 73.3* 13.5 9.91 39.4
 BIS1 −0.770 14.0 75.1* 12.8 9.37 35.2
 FAS −1.810a 13.5 75.1 12.9 9.42 36.5
 EKFC −2.145a 13.6 71.5* 13.4 9.73 38.3
Female(N = 226)
 CKD-EPI 1.260a 18.0 58.8 15.0 10.37 39.8
 LMR −1.950 13.7 64.2 13.1 9.93 34.1
 BIS1 0.370a 13.1 71.7** 12.9 9.39 35.4
 FAS −1.590 12.8 67.7* 13.4 9.45 35.8
 EKFC −1.815a 14.0 64.6* 13.3 9.76 34.5
mGFR≥60 ml/min/1.73m2(N = 158)
 CKD-EPI 1.590 23.8 80.4 17.6 13.96 39.9
 LMR −7.860a 20.5 81.6 18.9 14.37 44.9
 BIS1 −8.285a 19.9 79.7 18.8 14.57 47.5
 FAS −6.480a 21.4 77.2 18.9 14.60 46.8
 EKFC −5.760a 21.7 81.6 18.3 13.81 44.9
mGFR<60 ml/min/1.73m2(N = 454)
 CKD-EPI 0.720a 15.1 59.5 13.2 9.50 36.6
 LMR −2.065a 12.3 65.9* 10.8 8.20 34.8
 BIS1 1.220a 11.9 71.8** 10.0 7.42 31.1
 FAS −0.640 11.7 70.7** 10.3 7.70 32.6
EKFC −1.120a 13.1 64.5** 11.1 8.29 34.1
Diabetic (N = 293)
 CKD-EPI 0.730 16.3 65.5 13.6 10.15 36.9
 LMR −3.150a 12.9 69.6 12.7 9.36 37.9
 BIS1 −0.370 12.8 74.1* 11.9 8.71 35.8
 FAS −1.820a 12.3 71.7* 12.0 8.83 36.2
 EKFC −1.990a 12.5 70.0* 12.5 9.17 36.5
Non-diabetic(N = 319)
 CKD-EPI 0.960a 16.7 64.3 15.2 11.1 37.9
 LMR −2.830a 14.0 70.2* 14.0 10.2 37.0
 BIS1 0.110 13.0 73.7** 13.7 9.8 34.8
 FAS −1.760 13.9 73.0** 14.0 10.1 36.4
 EKFC −1.950a 14.7 68.0* 14.0 10.2 37.3
  1. Median difference in bias is the difference between equation biases (estimated GFR minus measured GFR); P30 Percentage of estimates within 30% of the measured value, IQR The inter-quartile range of difference, RMSE Root mean square error, MAE Mean absolute error, CKD-EPI Chronic kidney disease epidemiology collaboration, LMR Lund-Malmö Revised, BIS1 Berlin Initiative Study 1, FAS Full age spectrum equation, EKFC European Kidney Function Consortium
  2. a P < 0.05, compared with mGFR; * P < 0.05, **P < 0.001,compared with CKD-EPI