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Table 3 Diagnostic value analysis of the five GFR-Estimating Equation

From: Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients

  Rs CCC(95%CI) ROCAUC(95%CI) Sensitivity Specificity Youden index Kappa
All Participants(N = 612)
 CKD-EPI 0.872a 0.843 (0.820,0.863) 0.925 (0.902,0.945)* 87.7 83.5 0.712 0.438**
 LMR 0.873a 0.855 (0.833,0.874) 0.926 (0.903,0.946)* 86.6 84.8 0.714 0.473**
 BIS1 0.871a 0.863 (0.841,0.882) 0.926 (0.902,0.945)* 82.4 88.6 0.710 0.485**
 FAS 0.873a 0.864 (0.843,0.883) 0.927 (0.903,0.947)* 87.7 84.2 0.718 0.482**
 EKFC 0.874a 0.849 (0.827,0.869) 0.927 (0.912,0.952)* 85.2 86.7 0.720 0.477**
Participants Aged 65–79 Years(N = 444)
 CKD-EPI 0.898a 0.858 (0.834,0.879) 0.943 (0.917,0.962)* 89.3 85.6 0.750 0.491**
 LMR 0.896a 0.870 (0.847,0.890) 0.943 (0.917,0.962)* 87.2 88.8 0.760 0.478**
 BIS1 0.896a 0.880 (0.857,0.899) 0.943 (0.917,0.962)* 86.8 88.8 0.756 0.489**
 FAS 0.898a 0.880 (0.858,0.899) 0.944 (0.918,0.963)* 88.4 88.0 0.764 0.488**
 EKFC 0.898a 0.863 (0.839,0.884) 0.943 (0.918,0.963)* 88.4 88.0 0.764 0.487**
Participants Aged ≥80 Years(N = 168)
 CKD-EPI 0.760a 0.773 (0.707,0.825) 0.858 (0.796,0.907)* 84.4 75.8 0.602 0.441**
 LMR 0.762a 0.784 (0.720,0.836) 0.858 (0.796,0.907)* 84.4 75.8 0.602 0.438**
 BIS1 0.762a 0.788 (0.724,0.838) 0.859 (0.797,0.908)* 84.4 75.8 0.602 0.453**
 FAS 0.762a 0.791 (0.727,0.842) 0.860 (0.798,0.909)* 84.4 75.8 0.602 0.449**
 EKFC 0.761a 0.784 (0.719,0.835) 0.858 (0.796,0.907)* 83.7 75.8 0.595 0.429**
Male(N = 386)
 CKD-EPI 0.862a 0.833 (0.801,0.860) 0.911 (0.878,0.937)* 85.5 84.5 0.700 0.490**
 LMR 0.886a 0.840 (0.808,0.867) 0.913 (0.881,0.939)* 85.2 85.4 0.706 0.431**
 BIS1 0.865a 0.838 (0.807,0.864) 0.914 (0.882,0.940)* 83.0 86.4 0.695 0.469**
 FAS 0.865a 0.841 (0.809,0.867) 0.914 (0.881,0.940)* 87.3 82.5 0.698 0.464**
 EKFC 0.865a 0.838 (0.806,0.865) 0.913 (0.880,0.939)* 84.8 85.4 0.702 0.442**
Female(N = 226)
 CKD-EPI 0.891a 0.852 (0.820,0.879) 0.951 (0.914,0.975)* 93.0 85. 5 0.784 0.467**
 LMR 0.892a 0.872 (0.841,0.898) 0.953 (0.916,0.976)* 91.8 87.3 0.791 0.537**
 BIS1 0.889a 0.894 (0.864,0.917) 0.950 (0.913,0.975)* 91.8 87.3 0.791 0.507**
 FAS 0.890a 0.885 (0.855,0.909) 0.950 (0.913,0.975)* 91.8 87.3 0.791 0.508**
 EKFC 0.890a 0.862 (0.829,0.888) 0.951 (0.914,0.975)* 92.4 87.3 0.797 0.528**
Diabetic (N = 293)
 CKD-EPI 0.869a 0.851 (0.819,0.878) 0.934 (0.900,0.960)* 84.7 90.8 0.754 0.484**
 LMR 0.869a 0.858 (0.825,0.885) 0.934 (0.899,0.959)* 87.3 86.2 0.734 0.462**
 BIS1 0.869a 0.866 (0.835,0.891) 0.934 (0.900,0.960)* 84.7 90.8 0.754 0.466**
 FAS 0.872a 0.872 (0.841,0.897) 0.935 (0.900,0.960)* 83.3 90.8 0.741 0.478**
 EKFC 0.871a 0.858 (0.825,0.884) 0.935 (0.901,0.961)* 87.7 86.2 0.739 0.477**
Non-diabetic(N = 319)
 CKD-EPI 0.871a 0.834 (0.801,0.862) 0.919 (0.884,0.947)* 85.8 86.0 0.719 0.480**
 LMR 0.872a 0.850 (0.818,0.877) 0.920 (0.885,0.947)* 87.6 83.9 0.715 0.481**
 BIS1 0.867a 0.859 (0.828,0.885) 0.918 (0.882,0.946)* 88.1 82.8 0.709 0.500**
 FAS 0.870a 0.856 (0.824,0.883) 0.920 (0.884,0.947)* 87.2 86.0 0.732 0.484**
 EKFC 0.872a 0.841 (0.808,0.869) 0.919 (0.884,0.947)* 88.9 83.9 0.728 0.474**
  1. The CCC ranges between −1 and 1; 1 denotes perfect agreement, greater than 0.990, almost perfect agreement; 0.950 to 0.990, substantial agreement; 0.900 to 0.949, moderate agreement; and less than 0.900, poor agreement. Kappa value 0.21–0.40 is considered mild agreement, 0.41–0.60 moderate agreement, 0.61–0.80 substantial agreement, and 0.81–1.00 near perfect agreement
  2. Abbreviations: AUC Area under the receiver operating characteristic curve, CCC Concordance correlation coefficient; 95%CI 95% confidence interval. CKD-EPI Chronic kidney disease epidemiology collaboration, LMR Lund-Malmö Revised, BIS1 Berlin Initiative Study 1, FAS Full age spectrum equation, EKFC European Kidney Function Consortium, EKFC European Kidney Function Consortium. a P < 0.01, * P < 0.05, ** P < 0.001 compared with mGFR