Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients

Xia, Fangxiao; Hao, Wenke; Liang, Jinxiu; Wu, Yanhua; Yu, Feng; Hu, Wenxue; Zhao, Zhi; Liu, Wei

doi:10.1186/s12877-021-02428-y

BMC Geriatrics

Table 3 Diagnostic value analysis of the five GFR-Estimating Equation

From: Applicability of Creatinine-based equations for estimating glomerular filtration rate in elderly Chinese patients

	Rs	CCC(95%CI)	ROC^AUC(95%CI)	Sensitivity	Specificity	Youden index	Kappa
All Participants(N = 612)
CKD-EPI	0.872^a	0.843 (0.820,0.863)	0.925 (0.902,0.945)^*	87.7	83.5	0.712	0.438**
LMR	0.873^a	0.855 (0.833,0.874)	0.926 (0.903,0.946)^*	86.6	84.8	0.714	0.473**
BIS1	0.871^a	0.863 (0.841,0.882)	0.926 (0.902,0.945)^*	82.4	88.6	0.710	0.485**
FAS	0.873^a	0.864 (0.843,0.883)	0.927 (0.903,0.947)^*	87.7	84.2	0.718	0.482**
EKFC	0.874^a	0.849 (0.827,0.869)	0.927 (0.912,0.952)^*	85.2	86.7	0.720	0.477**
Participants Aged 65–79 Years(N = 444)
CKD-EPI	0.898^a	0.858 (0.834,0.879)	0.943 (0.917,0.962)^*	89.3	85.6	0.750	0.491**
LMR	0.896^a	0.870 (0.847,0.890)	0.943 (0.917,0.962)^*	87.2	88.8	0.760	0.478**
BIS1	0.896^a	0.880 (0.857,0.899)	0.943 (0.917,0.962)^*	86.8	88.8	0.756	0.489**
FAS	0.898^a	0.880 (0.858,0.899)	0.944 (0.918,0.963)^*	88.4	88.0	0.764	0.488**
EKFC	0.898^a	0.863 (0.839,0.884)	0.943 (0.918,0.963)^*	88.4	88.0	0.764	0.487**
Participants Aged ≥80 Years(N = 168)
CKD-EPI	0.760^a	0.773 (0.707,0.825)	0.858 (0.796,0.907)^*	84.4	75.8	0.602	0.441**
LMR	0.762^a	0.784 (0.720,0.836)	0.858 (0.796,0.907)^*	84.4	75.8	0.602	0.438**
BIS1	0.762^a	0.788 (0.724,0.838)	0.859 (0.797,0.908)^*	84.4	75.8	0.602	0.453**
FAS	0.762^a	0.791 (0.727,0.842)	0.860 (0.798,0.909)^*	84.4	75.8	0.602	0.449**
EKFC	0.761^a	0.784 (0.719,0.835)	0.858 (0.796,0.907)^*	83.7	75.8	0.595	0.429**
Male(N = 386)
CKD-EPI	0.862^a	0.833 (0.801,0.860)	0.911 (0.878,0.937)^*	85.5	84.5	0.700	0.490**
LMR	0.886^a	0.840 (0.808,0.867)	0.913 (0.881,0.939)^*	85.2	85.4	0.706	0.431**
BIS1	0.865^a	0.838 (0.807,0.864)	0.914 (0.882,0.940)^*	83.0	86.4	0.695	0.469**
FAS	0.865^a	0.841 (0.809,0.867)	0.914 (0.881,0.940)^*	87.3	82.5	0.698	0.464**
EKFC	0.865^a	0.838 (0.806,0.865)	0.913 (0.880,0.939)^*	84.8	85.4	0.702	0.442**
Female(N = 226)
CKD-EPI	0.891^a	0.852 (0.820,0.879)	0.951 (0.914,0.975)^*	93.0	85. 5	0.784	0.467**
LMR	0.892^a	0.872 (0.841,0.898)	0.953 (0.916,0.976)^*	91.8	87.3	0.791	0.537**
BIS1	0.889^a	0.894 (0.864,0.917)	0.950 (0.913,0.975)^*	91.8	87.3	0.791	0.507**
FAS	0.890^a	0.885 (0.855,0.909)	0.950 (0.913,0.975)^*	91.8	87.3	0.791	0.508**
EKFC	0.890^a	0.862 (0.829,0.888)	0.951 (0.914,0.975)^*	92.4	87.3	0.797	0.528**
Diabetic (N = 293)
CKD-EPI	0.869^a	0.851 (0.819,0.878)	0.934 (0.900,0.960)^*	84.7	90.8	0.754	0.484**
LMR	0.869^a	0.858 (0.825,0.885)	0.934 (0.899,0.959)^*	87.3	86.2	0.734	0.462**
BIS1	0.869^a	0.866 (0.835,0.891)	0.934 (0.900,0.960)^*	84.7	90.8	0.754	0.466**
FAS	0.872^a	0.872 (0.841,0.897)	0.935 (0.900,0.960)^*	83.3	90.8	0.741	0.478**
EKFC	0.871^a	0.858 (0.825,0.884)	0.935 (0.901,0.961)^*	87.7	86.2	0.739	0.477**
Non-diabetic(N = 319)
CKD-EPI	0.871^a	0.834 (0.801,0.862)	0.919 (0.884,0.947)^*	85.8	86.0	0.719	0.480**
LMR	0.872^a	0.850 (0.818,0.877)	0.920 (0.885,0.947)^*	87.6	83.9	0.715	0.481**
BIS1	0.867^a	0.859 (0.828,0.885)	0.918 (0.882,0.946)^*	88.1	82.8	0.709	0.500**
FAS	0.870^a	0.856 (0.824,0.883)	0.920 (0.884,0.947)^*	87.2	86.0	0.732	0.484**
EKFC	0.872^a	0.841 (0.808,0.869)	0.919 (0.884,0.947)^*	88.9	83.9	0.728	0.474**

The CCC ranges between −1 and 1; 1 denotes perfect agreement, greater than 0.990, almost perfect agreement; 0.950 to 0.990, substantial agreement; 0.900 to 0.949, moderate agreement; and less than 0.900, poor agreement. Kappa value 0.21–0.40 is considered mild agreement, 0.41–0.60 moderate agreement, 0.61–0.80 substantial agreement, and 0.81–1.00 near perfect agreement
Abbreviations: AUC Area under the receiver operating characteristic curve, CCC Concordance correlation coefficient; 95%CI 95% confidence interval. CKD-EPI Chronic kidney disease epidemiology collaboration, LMR Lund-Malmö Revised, BIS1 Berlin Initiative Study 1, FAS Full age spectrum equation, EKFC European Kidney Function Consortium, EKFC European Kidney Function Consortium. ^a P < 0.01, * P < 0.05, ** P < 0.001 compared with mGFR

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