Grip strength from midlife as an indicator of later-life brain health and cognition: evidence from a British birth cohort

Table 3 Associations between grip strength trajectory group membership and brain health and cognitive measures at 69–71

	Group membership (vs reference, n = 275)
	Low (n = 93)		High (n = 60)
*Brain health measures*
WBV (cm³)	-13.38* (-24.12, -2.64)	M:	-3.65 (-21.92, 14.62)
WBV (cm³)	-13.38* (-24.12, -2.64)	F:	18.30* (1.34, 35.29)
Global WMHV (mL)	0.86 (0.67, 1.11)		1.07 (0.80, 1.44)
*Cognitive measures*
PACC (z-score)	-0.06 (-0.20, 0.09)		-0.01 (-0.18, 0.16)
Matrix reasoning (z-score)‡	-0.33† (-0.58, -0.13)		-0.08 (-0.34, 0.14)

*p < 0.05
† BCa bootstrap 95% CI does not contain 0
‡ 95% CIs obtained from BCa bootstrap with 2,000 replicates
Coefficients (95 % CIs) are derived from multivariable linear regression models or GLMs and give the estimated mean difference between the low or high group versus the reference group for WBV and the multiplicative difference between low or high group versus the reference group for WMHV. All models included 428 participants with complete baseline covariates (age 53), and were adjusted for sex, age at scan/visit, height, weight, physical activity, and vascular risk score at age 53, adult SEP, education, and a binary indicator of cognitive or neurological impairment at age 69–71. Additional adjustments were for weight squared (WMHV), TIV (brain measures), and childhood cognitive ability (cognitive measures). Values given to 2 d.p.

ISSN: 1471-2318