Prediction of biological age and all-cause mortality by 12-lead electrocardiogram in patients without structural heart disease

Table 4 The predictive capability for all-cause death and cardiovascular death using CA and biological age by three algorithms

	CA			BA			BA_E			BA_EC
	AUC	95% CI	P-value	AUC	95% CI	P-value	AUC	95% CI	P-value	AUC	95% CI	P-value
All-cause death
Total	0.725	0.654–0.796	< 0.001	0.731	0.662–0.799	< 0.001	0.657	0.584–0.730	< 0.001	0.685	0.616–0.754	< 0.001
CA of 40–59 years	0.573	0.455–0.691	0.404	0.592	0.437–0.746	0.293	0.583	0.410–0.756	0.342	0.586	0.416–0.756	0.325
CA of 60–74 years	0.482	0.349–0.615	0.783	0.619	0.489–0.750	0.071	0.702	0.579–0.826	0.002	0.697	0.574–0.820	0.002
CA ≥75 years	0.680	0.563–0.797	0.001	0.575	0.477–0.673	0.197	0.534	0.414–0.655	0.556	0.539	0.421–0.658	0.498
CV death
Total	0.674	0.556–0.791	0.003	0.682	0.556–0.807	0.002	0.685	0.568–0.802	0.002	0.692	0.573–0.811	0.001
CA of 40–59 years	0.605	0.451–0.758	0.338	0.521	0.319–0.724	0.845	0.473	0.258–0.689	0.808	0.481	0.270–0.692	0.862
CA of 60–74 years	0.549	0.282–0.817	0.653	0.673	0.452–0.894	0.113	0.811	0.704–0.918	0.004	0.803	0.686–0.921	0.005
CA ≥75 years	0.599	0.414–0.783	0.306	0.615	0.461–0.769	0.232	0.686	0.517–0.856	0.053	0.689	0.524–0.854	0.050

Abbreviations: CA chronological age, BA biological age by principal component analysis method, BA_E biological age by the Klemera and Doubal’s method without adjustment for chronological age, BA_EC biological age by the Klemera and Doubal’s method with adjustment for chronological age, AUC area under the curve, CI confidence interval

ISSN: 1471-2318