| N event/N total | N event/N total | HR | Weight |
---|---|---|---|---|
(anaemia)d | (no anaemia)e | (95% CI) | % | |
Iron Deficiency | ||||
 Leiden 85-plus Study | 6/98 | 11/262 | 1.48 (0.64 to 3.40) | 30.8 |
 Newcastle 85+ study | 13/109 | 12/309 | 2.41 (1.35 to 4.32) | 47.6 |
 TOOTH | 4/33 | 9/64 | 0.88 (0.30 to 2.53) | 21.6 |
Total (I2 = 32%) |  |  | 1.67 (0.96 to 2.90) | 100.0 |
Vitamin B12 Deficiency | ||||
 Leiden 85-plus Study | 16/98 | 37/262 | 1.03 (0.59 to 1.79) | 40.6 |
 Newcastle 85+ study | 25/109 | 49/309 | 1.35 (0.85 to 2.13) | 59.4 |
 TOOTH | 0/28 | 1/54 | f | 0 |
Total (I2 = 0%) |  |  | 1.21 (0.85 to 1.72) | 100.0 |
Folate Deficiency | ||||
 Leiden 85-plus Study | 10/98 | 9/262 | 2.84 (1.45 to 5.54) | 51.2 |
 Newcastle 85+ study | 2/109 | 12/309 | 0.56 (0.14 to 2.30) | 31.9 |
 TOOTH | 1/28 | 1/54 | 1.20 (0.11 to 12.91) | 17.0 |
Total (I2 = 54%) |  |  | 1.46 (0.46 to 4.60) | 100.0 |
Low eGFR | ||||
 Leiden 85-plus Study | 14/98 | 40/263 | 1.09 (0.61 to 1.94) | 36.3 |
 Newcastle 85+ study | 41/109 | 64/309 | 1.97 (1.32 to 2.94) | 52.7 |
 TOOTH | 3/33 | 0/64 | 2.41 (0.68 to 8.52) | 11.0 |
Total (I2 = 35%) |  |  | 1.62 (1.04 to 2.54) | 100.0 |
High CRP | ||||
 Leiden 85-plus Study | 33/98 | 64/263 | 1.55 (1.00 to 2.42) | 46.0 |
 Newcastle 85+ study | 29/109 | 63/308 | 1.27 (0.83 to 1.95) | 48.1 |
 TOOTH | 3/33 | 3/63 | 1.45 (0.42 to 5.00) | 5.9 |
Total (I2 = 0%) |  |  | 1.40 (1.04 to 1.89) | 100.0 |
Increase per Additional Abnormal Determinantc | ||||
 Leiden 85-plus Study | 41,37,18,2,0,0/98 | 139,91,30,2,0,0/263 | 1.35 (1.06 to 1.73) | 44.0 |
 Newcastle 85+ study | 30,52,23,4,0,0/109 | 149,124,32,4, 0,0/309 | 1.58 (1.25 to 1.98) | 50.3 |
 TOOTH | 23,9,1,0,0,0/33 | 50,14,0,0,0,0/64 | 1.28 (0.65 to 2.53) | 5.7 |
Total (I2 = 0%) |  |  | 1.46 (1.24 to 1.71) | 100.0 |
≥2 Combination of Determinantsc | ||||
 Leiden 85-plus Study | 20/98 | 33/263 | 1.87 (1.12 to 3.12) | 41.1 |
 Newcastle 85+ study | 27/109 | 36/309 | 2.02 (1.30 to 3.13) | 56.3 |
 TOOTH | 1/33 | 0/64 | 1.98 (0.25 to 15.53) | 2.6 |
Total (I2 = 0%) |  |  | 1.95 (1.40 to 2.71) | 100.0 |