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Table 4 Associate between FRS at baseline (wave 1) and combined mortality and incident frailty during the follow-up (wave2-wave3)

From: The Framingham risk score is associated with incident frailty, or is it?

  Model 1 a Model 2 b Model 3 c
HR (95% CI) p Value HR (95% CI) p Value HR (95% CI) p Value
Generalized FRS [2008] (n=3,033) 1.06 (1.04 to 1.09) <0.001 1.05 (1.02 to 1.08) <0.001 1.02 (0.99 to 1.05) 0.327
Generalized FRS [2008] after excluding incident CVD (n=2,794) 1.06 (1.03 to 1.09) <0.001 1.05 (1.02 to 1.09) <0.001 1.01 (0.98 to 1.05) 0.381
Generalized FRS [2008] after excluding baseline depression (n=2,407) 1.08 (1.04 to 1.11) <0.001 1.07 (1.03 to 1.11) <0.001 1.03 (1.00 to 1.07) 0.078
Updated FRS [2015]d (n=3,033) 1.16 (1.11 to 1.21) <0.001 1.13 (1.08 to 1.19) <0.001 1.04 (0.98 to 1.10) 0.198
  1. aAdjusted for sex
  2. bAdjusted for sex, education, marital status, obesity, comorbidity burden, cognitive function score
  3. cAdjusted for sex, age, education, marital status, obesity, comorbidity burden, cognitive function score
  4. dUpdated FRS algorithm https://www.thecalculator.co/health/Framingham-Risk-Score-Calculator-for-Coronary-Heart-Disease-745.html