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Table 3 Associate between the Framingham Risk Score (FRS) at baseline (wave 1) and incident frailty during the follow-up (wave2-wave3)

From: The Framingham risk score is associated with incident frailty, or is it?

  Model 1 a Model 2 b Model 3 c
HR (95% CI) P Value HR (95% CI) P Value HR (95% CI) P Value
Generalized FRS [2008](n=2,901) 1.03 (1.01 to 1.06) 0.013 1.03 (1.00 to 1.06) 0.030 1.00 (0.97 to 1.03) 0.773
Generalized FRS [2008] after excluding incident CVD (n=2,669) 1.03 (1.01 to 1.06) 0.017 1.03 (1.00 to 1.06) 0.049 0.99 (0.96 to 1.03) 0.651
Generalized FRS [2008] after excluding baseline depression (n=2,311) 1.05 (1.01 to 1.08) 0.005 1.05 (1.01 to 1.08) 0.010 1.01 (0.97 to 1.05) 0.668
Updated FRS [2015]d (n=2,901) 1.10 (1.05 to 1.16) <0.001 1.08 (1.02 to 1.14) 0.009 0.99 (0.93 to 1.07) 0.865
  1. aAdjusted for sex
  2. bAdjusted for sex, education, marital status, obesity, comorbidity burden, cognitive function
  3. cAdjusted for sex, age, education, marital status, obesity, comorbidity burden, cognitive function
  4. dUpdated FRS algorithm https://www.thecalculator.co/health/Framingham-Risk-Score-Calculator-for-Coronary-Heart-Disease-745.html