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Table 5 Odds ratios (ORs) for cognitive decline according to the exposure combination

From: Interaction between cognitive leisure activity and long-chain polyunsaturated fatty acid intake on global cognitive decline in a Japanese longitudinal cohort study: National Institute for Longevity Sciences-Longitudinal Study of Aging

 

Fatty acid

Exposure combination

LCPUFA

DHA

EPA

ARA

ORs (95% CIs)

Crude Model

 

Fatty acid intake (L)

x

Art appreciation (L)

1 (Reference)

1 (Reference)

1 (Reference)

1 (Reference)

Fatty acid intake (L)

x

Art appreciation (H)

1.03 (0.58–1.85)

0.98 (0.55–1.75)

0.93 (0.51–1.69)

1.01 (0.57–1.80)

Fatty acid intake (H)

x

Art appreciation (L)

1.01 (0.64–1.58)

1.09 (0.69–1.71)

1.06 (0.68–1.67)

0.96 (0.61–1.51)

Fatty acid intake (H)

x

Art appreciation (H)

0.29 (0.14–0.60)

0.32 (0.15–0.67)

0.37 (0.18–0.73)

0.26 (0.12–0.56)

Model I

Fatty acid intake (L)

x

Art appreciation (L)

1 (Reference)

1 (Reference)

1 (Reference)

1 (Reference)

Fatty acid intake (L)

x

Art appreciation (H)

1.00 (0.55–1.82)

0.97 (0.54–1.75)

0.91 (0.50–1.67)

0.98 (0.54–1.76)

Fatty acid intake (H)

x

Art appreciation (L)

0.99 (0.62–1.57)

1.09 (0.69–1.74)

1.04 (0.66–1.66)

0.95 (0.60–1.51)

Fatty acid intake (H)

x

Art appreciation (H)

0.30 (0.15–0.63)

0.34 (0.16–0.71)

0.38 (0.19–0.76)

0.28 (0.13–0.60)

Model II

Fatty acid intake (L)

x

Art appreciation (L)

1 (Reference)

1 (Reference)

1 (Reference)

1 (Reference)

Fatty acid intake (L)

x

Art appreciation (H)

0. 94 (0.47–1.86)

0.96 (0.48–1.90)

0.80 (0.40–1.60)

0.95 (0.49–1.85)

Fatty acid intake (H)

x

Art appreciation (L)

0.84 (0.49–1.42)

1.01 (0.59–1.71)

0.89 (0.53–1.51)

0.94 (0.55–1.60)

Fatty acid intake (H)

x

Art appreciation (H)

0.25 (0.11–0.56)

0.29 (0.13–0.65)

0.33 (0.15–0.72)

0.25 (0.10–0.59)

  1. Note: Multiple logistic analysis
  2. Model I: Adjusted for sex and age
  3. Model II: Adjusted for sex and age; MMSE score; BMI; education level; marital status; smoking status; alcohol consumption; energy intake; physical activity; employment status; depressive tendency; and history of hypertension, hyperlipidemia, ischemic heart disease stroke and diabetes
  4. Fatty acid intake was divided into two groups (high,low) based on the median values according to sex. Art appreciation was divided into two groups based on the frequency of participation: “at least once or more per month” (high); “once or several times per year or less” (low)
  5. ARA, arachidonic acid; CI, confidence interval; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; L, low; LCPUFAs, long-chain polyunsaturated fatty acids; H, high; OR, odds ratio