Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study

BMC Geriatrics

Table 2 Pathological MRI findings

	Total n/N (%)	Female n/N (%)	Male n/N (%)	Unadjusted OR (†) (95% CI)	p-value	Adjusted OR (††) (95% CI)	p-value
≥1 pathological imaging result	278/410 (68)	108/182 (59)	170/228 (75)	0.5 (0.33-0.76)	0.001^*	0.43 (0.28-0.66)	0.0002*
Pathological WMH	154/410 (38)	74/182 (41)	80/228 (35)	1.3 (0.9-1.9)	0.25	1.13 (0.7- 1.7)	0.57
Old infarct	78/396 (20)	28/175 (16)	50/221 (23)	0.65 (0.4-1.1)	0.10	0.62 (0.4-1.0)	0.07
Lacunes	142/410 (35)	51/182 (28)	91/228 (40)	0.6 (0.4-0.9)	0.01^*	0.53 (0.3-0.8)	0.003*
Microbleeds	76/410 (19)	33/182 (18)	43/228 (19)	0.95 (0.6-1.6)	0.85	0.93 (0.6-1.5)	0.78
Medial temporal lobe atrophy	125/410 (30)	34/182 (19)	91/228 (40)	0.35 (0.2-0.6)	0.001^*	0.35 (0.2-0.6)	0.001*
Posterior atrophy	44/410 (11)	17/182 (9)	27/228 (12)	0.77 (0.4-1.5)	0.42	0.57 (0.3-1.1)	0.11
Evans index	17/410 (4)	6/182 (3)	11/228 (5)	0.67 (0.2-1.9)	0.44	0.7 (0.3-1.9)	0.49

The relationship between sex and pathological imaging findings was modelled using logistic regression with male sex as the reference group. Values are displayed as frequencies (%) for all patients and grouped by sex
(*) indicates significant difference in pathological findings. WMH white matter hyperintensities, path pathology, Evans index measurement of ventricle size, OR odds ratio. The analyses were adjusted for age to account for age as a potential confounding variable. (†)Unadjusted OR = OR for women compared to men. (††)Adjusted OR = OR for women compared to men and adjusted for age. * indicating statistically significant odds ratio

ISSN: 1471-2318