Skip to main content

Table 4 Associations between change in sleep parameters and change in blood pressure or change in antihypertensive medication use from baseline to month 4, in the control group

From: The longitudinal association between the use of antihypertensive medications and 24-hour sleep in nursing homes: results from the randomized controlled COSMOS trial

Outcomea Exposure Unadjusted association (95 % CI) p-value Adjusted associationb (95 % CI) p-value n
Total sleep time Anti hypertensivesc 15.6 (-74.0 – 105.2) 0.73 24.0 (-71.5 – 119.5) 0.62 39
Total sleep time Systolic blood pressured 23.5 (3.2 – 43.8) 0.02 25.0 (4.5 – 45.5) 0.02 38
Sleep onset latency Anti hypertensivesc -44.8 (-86.5 – -3.1) 0.04 -51.1 (-95.6 – -7.4) 0.02 39
Sleep onset latency Systolic blood pressured -12.7 (-20.9 – -4.4) 0.01 -13.7 (-22.0 – -5.4) 0.00 38
Wake after sleep onset Anti hypertensivesc -8.7 (-49.5 – 32.0) 0.67 -12.7 (-56.0 – 30.6) 0.57 39
Wake after sleep onset Systolic blood pressured -3.7 (-13.9 – 6.5) 0.48 -2.8 (-13.1 – 7.6) 0.60 38
Daytime sleep Anti hypertensivesc 61.0 (4.3 – 117.8) 0.035 50.3 (4.8-95.6)) 0.03 39
Daytime sleep Systolic blood pressured 3.7 (-8.4 – 15.8) 0.55 1.9 (-10.1 – 13.9) 0.76 38
Early morning awakening Anti hypertensivec -20.4 (-63.2 – 22.3) 0.35 -13.1 (-59.0 – 32.8) 0.58 39
Early morning awakening Systolic blood pressured -9.6 (-20.2 – 1.0) 0.08 -9.1 (-19.9 – 1.7) 0.1 38
  1. aReported as average minutes per day/night
  2. bAdjusted for age, gender and hypertensive diagnoses at baseline (yes/ no)
  3. cAnti-hypertensive users compared to non-anti-hypertensive users or change in anti-hypertensive medication use from baseline to month 4 for a patient
  4. dIncrease in sleep parameter associated with 10 mmHg increase in systolic blood pressure, the association can be interpreted as between-patients association or within-patient association