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Table 2 Associations between sleep parameters and blood pressure or antihypertensive medication use at baseline, for both groups combined

From: The longitudinal association between the use of antihypertensive medications and 24-hour sleep in nursing homes: results from the randomized controlled COSMOS trial

Outcomea Exposure Unadjusted association (95 % CI) p-value Adjusted associationb (95 % CI) p-value N
Total sleep time Anti hypertensivesc -1.4 (-71.7 – 69.0) 0.97 14.1 (-63.7 – 91.9) 0.72 83
Total sleep time Systolic blood pressured -3.6 (-24.2 – 17.1) 0.73 -3.1 (-24.9 – 18.7) 0.78 79
Sleep onset latency Anti hypertensivesc -11.6 (-46.7 – 23.6) 0.53 -20.9 (-59.6 – 17.8) 0.29 83
Sleep onset latency Systolic blood pressured -0.9 (-11.2 – 9.3) 0.86 -2.4 (-13.1 – 8.3) 0.66 79
Wake after sleep onset Anti hypertensivesc -14.9 (-50.0 – 20.3) 0.40 -12.0 (-49.8 – 25.7) 0.53 83
Wake after sleep onset Systolic blood pressured 4.5 (-5.8 – 14.9) 0.39 4.3 (-6.2 – 14.7) 0.42 79
Daytime sleep Anti hypertensivesc 22.7 (-29.6 – 75.1) 0.39 31.8 (25.9 – 89.5) 0.28 82
Daytime sleep Systolic blood pressured -7.0 (-22.0 – 8.2) 0.36 -6.7 (-22.7 – 7.4) 0.41 78
Early morning awakening Anti hypertensivesc -10.6 (-39.8 – 18.6) 0.47 -7.0 (-38.8 – 24.8) 0.67 83
Early morning awakening Systolic blood pressured -4.9 (-13.1 – 3.4) 0.24 -3.9 (-12.5 – 4.7) 0.37 79
  1. aReported as average minutes per day/night
  2. bAdjusted for age, gender and hypertensive diagnoses at baseline (yes/ no)
  3. cAnti-hypertensive users compared to non-anti-hypertensive users
  4. dIncrease in sleep parameter associated with 10 mmHg increase in systolic blood pressure